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Structure of human cGAS

X-ray diffraction
2.04Å resolution
PDB entry 4lew coloured by chain, front view.
PDB entry 4lew coloured by chain, side view.
PDB entry 4lew coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclic GMP-AMP synthase
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-185433
Assembly 2
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Assembly Name: Cyclic GMP-AMP synthase
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-185433

Macromolecules

Cyclic GMP-AMP synthase
Chains: A, B
Length: 366 amino acids
Theoretical weight: 42.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N884 (Residues: 157-522; Coverage: 70%)
Gene names: C6orf150, CGAS, MB21D1
Pfam:
InterPro:
CATH:
Cyclic GMP-AMP synthase in PDB entry 4lew, assembly 1, front view.
Cyclic GMP-AMP synthase in PDB entry 4lew, assembly 1, side view.
Cyclic GMP-AMP synthase in PDB entry 4lew, assembly 1, top view.
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