4lkj › Citations

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.

Shi Y, Zhang W, Wang F, Qi J, Wu Y, Song H, Gao F, Bi Y, Zhang Y, Fan Z, Qin C, Sun H, Liu J, Haywood J, Liu W, Gong W, Wang D, Shu Y, Wang Y, Yan J, Gao GF
Science 342 243-7 (2013)
Related entries: 4kol, 4kom, 4kon, 4lcx, 4lkg, 4lkh, 4lki, 4lkk

Cited: 176 times
EuropePMC logo PMID: 24009358

Abstract

An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) → Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.

Reviews - 4lkj mentioned but not cited (1)

  1. New insights into influenza A specificity: an evolution of paradigms. Ji Y, White YJ, Hadden JA, Grant OC, Woods RJ. Curr Opin Struct Biol 44 219-231 (2017)

Articles - 4lkj mentioned but not cited (1)



Reviews citing this publication (34)

  1. Role of receptor binding specificity in influenza A virus transmission and pathogenesis. de Graaf M, Fouchier RA. EMBO J 33 823-841 (2014)
  2. Bat-derived influenza-like viruses H17N10 and H18N11. Wu Y, Wu Y, Tefsen B, Shi Y, Gao GF. Trends Microbiol 22 183-191 (2014)
  3. Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses. Shi Y, Wu Y, Zhang W, Qi J, Gao GF. Nat Rev Microbiol 12 822-831 (2014)
  4. Evolution of Influenza A Virus by Mutation and Re-Assortment. Shao W, Li X, Goraya MU, Wang S, Chen JL. Int J Mol Sci 18 E1650 (2017)
  5. Epidemiology, Evolution, and Pathogenesis of H7N9 Influenza Viruses in Five Epidemic Waves since 2013 in China. Su S, Gu M, Liu D, Cui J, Gao GF, Zhou J, Liu X. Trends Microbiol 25 713-728 (2017)
  6. The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase. Byrd-Leotis L, Cummings RD, Steinhauer DA. Int J Mol Sci 18 E1541 (2017)
  7. The Pandemic Threat of Emerging H5 and H7 Avian Influenza Viruses. Sutton TC. Viruses 10 E461 (2018)
  8. Transmission of influenza A viruses. Neumann G, Kawaoka Y. Virology 479-480 234-246 (2015)
  9. Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential. Richard M, Fouchier RA. FEMS Microbiol Rev 40 68-85 (2016)
  10. Structural insights into the design of novel anti-influenza therapies. Wu NC, Wilson IA. Nat Struct Mol Biol 25 115-121 (2018)
  11. Pandemic potential of avian influenza A (H7N9) viruses. Watanabe T, Watanabe S, Maher EA, Neumann G, Kawaoka Y. Trends Microbiol 22 623-631 (2014)
  12. H7N9: a low pathogenic avian influenza A virus infecting humans. Liu J, Xiao H, Wu Y, Liu D, Qi X, Shi Y, Gao GF. Curr Opin Virol 5 91-97 (2014)
  13. Adaptation of influenza viruses to human airway receptors. Thompson AJ, Paulson JC. J Biol Chem 296 100017 (2021)
  14. H7N9 Influenza Virus in China. Li C, Chen H. Cold Spring Harb Perspect Med 11 a038349 (2021)
  15. Avian influenza A (H7N9) virus infection in humans: epidemiology, evolution, and pathogenesis. Husain M. Infect Genet Evol 28 304-312 (2014)
  16. Carbohydrate CuAAC click chemistry for therapy and diagnosis. He XP, Zeng YL, Zang Y, Li J, Field RA, Chen GR. Carbohydr Res 429 1-22 (2016)
  17. The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses. Wang D, Zhu W, Yang L, Shu Y. Cold Spring Harb Perspect Med 11 a038620 (2021)
  18. Emerging HxNy Influenza A Viruses. Liu WJ, Wu Y, Bi Y, Shi W, Wang D, Shi Y, Gao GF. Cold Spring Harb Perspect Med 12 a038406 (2022)
  19. Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection. Gao YL, Du Y, Zhang C, Cheng C, Yang HY, Jin YF, Duan GC, Chen SY. Infect Drug Resist 13 3715-3725 (2020)
  20. Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses. Zhao C, Pu J. Viruses 14 2141 (2022)
  21. Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic. Liu WJ, Xiao H, Dai L, Liu D, Chen J, Qi X, Bi Y, Shi Y, Gao GF, Liu Y. Front Med 15 507-527 (2021)
  22. Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review. Munoz O, De Nardi M, van der Meulen K, van Reeth K, Koopmans M, Harris K, von Dobschuetz S, Freidl G, Meijer A, Breed A, Hill A, Kosmider R, Banks J, Stärk KD, Wieland B, Stevens K, van der Werf S, Enouf V, Dauphin G, Dundon W, Cattoli G, Capua I, FLURISK Consortium. Ecohealth 13 171-198 (2016)
  23. Pathogenicity and virulence of influenza. Liang Y. Virulence 14 2223057 (2023)
  24. Host-Virus Interaction: How Host Cells Defend against Influenza A Virus Infection. Zhang Y, Xu Z, Cao Y. Viruses 12 E376 (2020)
  25. The structural variability of the influenza A hemagglutinin receptor-binding site. Lazniewski M, Dawson WK, Szczepinska T, Plewczynski D. Brief Funct Genomics 17 415-427 (2018)
  26. Zoonotic Influenza and Human Health-Part 1: Virology and Epidemiology of Zoonotic Influenzas. Goneau LW, Mehta K, Wong J, L'Huillier AG, Gubbay JB. Curr Infect Dis Rep 20 37 (2018)
  27. Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors. Zhang M, Liu M, Bai S, Zhao C, Li Z, Xu J, Zhang X. Front Microbiol 12 777885 (2021)
  28. Single-virus force spectroscopy unravels molecular details of virus infection. Herrmann A, Sieben C. Integr Biol (Camb) 7 620-632 (2015)
  29. Tackling a novel lethal virus: a focus on H7N9 vaccine development. Isakova-Sivak I, Rudenko L. Expert Rev Vaccines 16 1-13 (2017)
  30. Did the Highly Pathogenic Avian Influenza A(H7N9) Viruses Emerged in China Raise Increased Threat to Public Health? Zhu W, Yang L, Shu Y. Vector Borne Zoonotic Dis 19 22-25 (2019)
  31. The Effects of Genetic Variation on H7N9 Avian Influenza Virus Pathogenicity. Huang SW, Wang SF. Viruses 12 E1220 (2020)
  32. H7N9: A killer in the making or a false alarm? Nailwal H, Kamra K, Lal SK. Can J Microbiol 60 425-429 (2014)
  33. Global distribution, receptor binding, and cross-species transmission of H6 influenza viruses: risks and implications for humans. Yan Z, Li Y, Huang S, Wen F. J Virol 97 e0137023 (2023)
  34. NSFC spurs significant basic research progress of respiratory medicine in China. Sun R, Xu F, Wang C, Dong E. Clin Respir J 11 271-284 (2017)

Articles citing this publication (140)



Quick links