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Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin

X-ray diffraction
3.1Å resolution
PDB entry 4wjg coloured by chain, front view.
PDB entry 4wjg coloured by chain, side view.
PDB entry 4wjg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero decamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Hemoglobin HbA complex
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Multimeric state: hetero decamer
Accessible surface area: 89334.03 Å2
Buried surface area: 28324.32 Å2
Dissociation area: 1,262.47 Å2
Dissociation energy (ΔGdiss): -3.43 kcal/mol
Dissociation entropy (TΔSdiss): 25.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-125229
Assembly 2
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Assembly Name: Hemoglobin HbA complex
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Multimeric state: hetero decamer
Accessible surface area: 89748.02 Å2
Buried surface area: 28484.85 Å2
Dissociation area: 1,259.33 Å2
Dissociation energy (ΔGdiss): -3.41 kcal/mol
Dissociation entropy (TΔSdiss): 25.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-125229
Assembly 3 (preferred)
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Assembly Name: Hemoglobin HbA complex
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Multimeric state: hetero decamer
Accessible surface area: 89201.24 Å2
Buried surface area: 28101.26 Å2
Dissociation area: 1,256.39 Å2
Dissociation energy (ΔGdiss): -3.44 kcal/mol
Dissociation entropy (TΔSdiss): 25.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-125229

Macromolecules

Hemoglobin subunit alpha
Chains: A, F, K, P, U, Z
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit alpha in PDB entry 4wjg, assembly 3, front view.
Hemoglobin subunit alpha in PDB entry 4wjg, assembly 3, side view.
Hemoglobin subunit alpha in PDB entry 4wjg, assembly 3, top view.
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Hemoglobin subunit beta
Chains: 1, B, G, L, Q, V
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Pfam: Globin
InterPro:
CATH: Globins
Hemoglobin subunit beta in PDB entry 4wjg, assembly 3, front view.
Hemoglobin subunit beta in PDB entry 4wjg, assembly 3, side view.
Hemoglobin subunit beta in PDB entry 4wjg, assembly 3, top view.
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Haptoglobin
Chains: 2, C, H, M, R, W
Length: 315 amino acids
Theoretical weight: 35.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00738 (Residues: 92-406; Coverage: 81%)
Gene name: HP
Pfam: Trypsin
InterPro:
CATH:
Haptoglobin in PDB entry 4wjg, assembly 3, front view.
Haptoglobin in PDB entry 4wjg, assembly 3, side view.
Haptoglobin in PDB entry 4wjg, assembly 3, top view.
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Iron-regulated surface determinant protein H
Chains: 3, D, I, N, S, X
Length: 146 amino acids
Theoretical weight: 16.88 KDa
Source organism: Staphylococcus aureus subsp. aureus N315
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99TD3 (Residues: 86-229; Coverage: 17%)
Gene names: SA1552, harA, isdH, sasI
Pfam: Iron Transport-associated domain
InterPro:
CATH: Immunoglobulin-like
Iron-regulated surface determinant protein H in PDB entry 4wjg, assembly 3, front view.
Iron-regulated surface determinant protein H in PDB entry 4wjg, assembly 3, side view.
Iron-regulated surface determinant protein H in PDB entry 4wjg, assembly 3, top view.
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Haptoglobin-hemoglobin receptor
Chains: 4, E, J, O, T, Y
Length: 343 amino acids
Theoretical weight: 36.85 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Komagataella pastoris
UniProt:
  • Canonical: I7BA80 (Residues: 36-378; Coverage: 93%)
Gene name: HpHbR
Pfam: Haptoglobin-hemoglobin receptor
CATH: Ferritin
Haptoglobin-hemoglobin receptor in PDB entry 4wjg, assembly 3, front view.
Haptoglobin-hemoglobin receptor in PDB entry 4wjg, assembly 3, side view.
Haptoglobin-hemoglobin receptor in PDB entry 4wjg, assembly 3, top view.
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