PDB 4wo5 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Serine/threonine-protein kinase B-raf
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Multimeric state: monomeric

Accessible surface area: 12551.9 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-147194

$Monomeric assembly 1 of PDB entry 4wo5 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4wo5 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 4wo5 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Serine/threonine-protein kinase B-raf
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Multimeric state: monomeric

Accessible surface area: 12281.01 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-147194

$Monomeric assembly 2 of PDB entry 4wo5 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4wo5 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 4wo5 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase B-raf;</li> <li class='image_legend_li'>1 copy of N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Serine/threonine-protein kinase B-raf

Chains: A, B
Length: 300 amino acids
Theoretical weight: 34.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli DH5[alpha]
UniProt:

Canonical: P15056 (Residues: 444-723; Coverage: 37%)

Gene names: BRAF, BRAF1, RAFB1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Protein kinase, ATP binding site
Serine/threonine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Serine/threonine-protein kinase B-raf in PDB entry 4wo5, assembly 1, front view.

Serine/threonine-protein kinase B-raf in PDB entry 4wo5, assembly 1, side view.

Serine/threonine-protein kinase B-raf in PDB entry 4wo5, assembly 1, top view.

FASTA Sequence


    >pdb|4wo5|A B

MGSSHHHHHHSSGETVRFQGRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELSG

PDBe-KB: UniProt Coverage View: P15056

Molecule details ›

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FASTA (Protein chains A, B)
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Structure Factors
SIFTS XML file with residue-level mappings

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BLAST P15056 (UniProt)

Protein Data Bank in Europe

Crystal structure of a BRAF kinase domain monomer

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 4wo5 › Structure analysis

Crystal structure of a BRAF kinase domain monomer

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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4wo5 › Structure analysis