EC 3.2.1.169: Protein O-GlcNAcase
Reaction catalysed:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine
Systematic name:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase
Alternative Name(s):
- BtGH84
- Glycoside hydrolase O-GlcNAcase
- O-GlcNAc hydrolase
- O-GlcNAcase
- OGA
GO terms
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)![The deposited structure of PDB entry 4zxl contains 1 copy of Pfam domain PF21774 (Hyaluronidase post-catalytic domain-like) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_Pfam_PF21774_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of Pfam domain <span class='highlight'>PF21774 (Hyaluronidase post-catalytic domain-like)</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4zxl contains 1 copy of Pfam domain PF07555 (beta-N-acetylglucosaminidase ) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_Pfam_PF07555_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of Pfam domain <span class='highlight'>PF07555 (beta-N-acetylglucosaminidase )</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4zxl contains 1 copy of Pfam domain PF02838 (Glycosyl hydrolase family 20, domain 2) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_Pfam_PF02838_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of Pfam domain <span class='highlight'>PF02838 (Glycosyl hydrolase family 20, domain 2)</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotationsStructure domains
CATH domains
1.20.58.460
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology:
Hyaluronidase post-catalytic domain-like
Occurring in:
![The deposited structure of PDB entry 4zxl contains 1 copy of CATH domain 1.20.58.460 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_CATH_1.20.58.460_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of CATH domain <span class='highlight'>1.20.58.460 (Methane Monooxygenase Hydroxylase; Chain G, domain 1)</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
3.20.20.80
Class:
Alpha Beta
Architecture:
Alpha-Beta Barrel
Topology:
TIM Barrel
Homology:
Glycosidases
Occurring in:
![The deposited structure of PDB entry 4zxl contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_CATH_3.20.20.80_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of CATH domain <span class='highlight'>3.20.20.80 (TIM Barrel)</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
![The deposited structure of PDB entry 4zxl contains 1 copy of CATH domain 3.30.379.10 (Chitobiase; domain 2) in O-GlcNAcase NagJ. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/4zxl_2_A_CATH_3.30.379.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4zxl</span> contains 1 copy of CATH domain <span class='highlight'>3.30.379.10 (Chitobiase; domain 2)</span> in <span class='highlight'>O-GlcNAcase NagJ</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")