Structure analysis

AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide

X-ray diffraction
2.77Å resolution
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 14742.86 Å2
Buried surface area: 852.97 Å2
Dissociation area: 426.48 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 6.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146673

Macromolecules

Chain: A
Length: 288 amino acids
Theoretical weight: 32.99 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P84092 (Residues: 159-236, 237-435; Coverage: 64%)
Gene name: Ap2m1
Pfam: Adaptor complexes medium subunit family
InterPro:
CATH: Mu homology domain, subdomain B
PDBe-KB: UniProt Coverage View: P84092  
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Chain: B
Length: 8 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13612 (Residues: 1008-1015; Coverage: 1%)
Gene names: CD49D, ITGA4
PDBe-KB: UniProt Coverage View: P13612  
181.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0
 
2468QYKSILQE
UniProt
P13612
Chains
Secondary structure
Flexibility predictions
Interaction interfaces

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