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Crystal structure of Thermus thermophilus CarH bound to adenosylcobalamin and a 26-bp DNA segment

X-ray diffraction
3.89Å resolution
PDB entry 5c8e coloured by chain, front view.
PDB entry 5c8e coloured by chain, side view.
PDB entry 5c8e coloured by chain, top view.
Source organism: Thermus thermophilus HB27
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Probable transcriptional regulator and DNA
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Multimeric state: hetero hexamer
Accessible surface area: 46489.52 Å2
Buried surface area: 26781.63 Å2
Dissociation area: 1,742.79 Å2
Dissociation energy (ΔGdiss): 25.78 kcal/mol
Dissociation entropy (TΔSdiss): 13.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118463
Assembly 2
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Assembly Name: Probable transcriptional regulator and DNA
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Multimeric state: hetero hexamer
Accessible surface area: 46974.69 Å2
Buried surface area: 26243.78 Å2
Dissociation area: 1,697.45 Å2
Dissociation energy (ΔGdiss): 22.79 kcal/mol
Dissociation entropy (TΔSdiss): 13.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118463

Macromolecules

Probable transcriptional regulator
Chains: A, B, C, D, E, F, G, H
Length: 305 amino acids
Theoretical weight: 33.32 KDa
Source organism: Thermus thermophilus HB27
Expression system: Escherichia coli
UniProt:
  • Canonical: Q746J7 (Residues: 1-285; Coverage: 100%)
Gene name: TT_P0056
Pfam:
InterPro:
CATH:
Probable transcriptional regulator in PDB entry 5c8e, assembly 1, front view.
Probable transcriptional regulator in PDB entry 5c8e, assembly 1, side view.
Probable transcriptional regulator in PDB entry 5c8e, assembly 1, top view.
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DNA chains I, K
Name: 26-mer DNA segment containing the CarH operator sequence (antisense strand)
Representative chains: I, K
Source organism: Thermus thermophilus HB27 [262724]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 8 KDa
26-mer DNA segment containing the CarH operator sequence (antisense strand) in PDB entry 5c8e, assembly 1, front view.
26-mer DNA segment containing the CarH operator sequence (antisense strand) in PDB entry 5c8e, assembly 1, side view.
26-mer DNA segment containing the CarH operator sequence (antisense strand) in PDB entry 5c8e, assembly 1, top view.
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DNA chains J, L
Name: 26-mer DNA segment containing the CarH operator sequence (sense strand)
Representative chains: J, L
Source organism: Thermus thermophilus HB27 [262724]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 7.97 KDa
26-mer DNA segment containing the CarH operator sequence (sense strand) in PDB entry 5c8e, assembly 1, front view.
26-mer DNA segment containing the CarH operator sequence (sense strand) in PDB entry 5c8e, assembly 1, side view.
26-mer DNA segment containing the CarH operator sequence (sense strand) in PDB entry 5c8e, assembly 1, top view.
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