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Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state

X-ray diffraction
2.141Å resolution
PDB entry 5ka3 coloured by chain, front view.
PDB entry 5ka3 coloured by chain, side view.
PDB entry 5ka3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
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Multimeric state: monomeric
Accessible surface area: 13249.45 Å2
Buried surface area: 1541.9 Å2
Dissociation area: 88.17 Å2
Dissociation energy (ΔGdiss): -3.92 kcal/mol
Dissociation entropy (TΔSdiss): 1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259
Assembly 2
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 13249.45 Å2
Buried surface area: 1541.9 Å2
Dissociation area: 88.17 Å2
Dissociation energy (ΔGdiss): -3.92 kcal/mol
Dissociation entropy (TΔSdiss): 1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 306 amino acids
Theoretical weight: 35.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18031 (Residues: 1-301; Coverage: 69%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 5ka3, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 5ka3, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 5ka3, assembly 1, top view.
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