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Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution

Source organisms:
Biochemical function: protein heterodimerization activity
Biological process: nucleosome assembly
Cellular component: chromosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 1
  3. Histone H2B type 1-C/E/F/G/I
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.2. Showing 1 copy in chain A.
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1. Showing 1 copy in chain C.
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 1-C/E/F/G/I. Showing 1 copy in chain D.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain M.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 5kgf contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.2
IPR000558
Domain description: Histone H2B
Occurring in:
  1. Histone H2B type 1-C/E/F/G/I
IPR002119
Domain description: Histone H2A
Occurring in:
  1. Histone H2A type 1
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.2
  2. Histone H4
  3. Histone H2A type 1
  4. Histone H2B type 1-C/E/F/G/I
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 1
  3. Histone H2B type 1-C/E/F/G/I
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR032454
Domain description: Histone H2A, C-terminal domain
Occurring in:
  1. Histone H2A type 1
IPR032458
Domain description: Histone H2A conserved site
Occurring in:
  1. Histone H2A type 1
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4

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