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GII.17 Kawasaki323 protruding domain in complex with Nanobody Nano-4

X-ray diffraction
1.72Å resolution
PDB entry 5o02 coloured by chain, front view.
PDB entry 5o02 coloured by chain, side view.
PDB entry 5o02 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein and IG-heavy chain
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Multimeric state: hetero dimer
Accessible surface area: 19336.62 Å2
Buried surface area: 2260.09 Å2
Dissociation area: 532.02 Å2
Dissociation energy (ΔGdiss): -3.33 kcal/mol
Dissociation entropy (TΔSdiss): 11.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207248

Macromolecules

Capsid protein
Chain: A
Length: 308 amino acids
Theoretical weight: 34.09 KDa
Source organism: Norovirus 13-BH-1/2013/GII.17
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A0A0A7CJV4 (Residues: 225-528; Coverage: 57%)
Pfam: Calicivirus coat protein C-terminal
InterPro: Calicivirus coat protein C-terminal
CATH:
Capsid protein in PDB entry 5o02, assembly 1, front view.
Capsid protein in PDB entry 5o02, assembly 1, side view.
Capsid protein in PDB entry 5o02, assembly 1, top view.
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Nanobody (VHH) Nano-4
Chain: C
Length: 124 amino acids
Theoretical weight: 13.59 KDa
Source organism: Vicugna pacos
Expression system: Escherichia coli
InterPro:
Nanobody (VHH) Nano-4 in PDB entry 5o02, assembly 1, front view.
Nanobody (VHH) Nano-4 in PDB entry 5o02, assembly 1, side view.
Nanobody (VHH) Nano-4 in PDB entry 5o02, assembly 1, top view.
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