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Molecular basis of human kinesin-8 function and inhibition

Electron Microscopy
4.8Å resolution
PDB entry 5ogc coloured by chain, ensemble of 2 models, front view.
PDB entry 5ogc coloured by chain, ensemble of 2 models, side view.
PDB entry 5ogc coloured by chain, ensemble of 2 models, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 42976.72 Å2
Buried surface area: 9169.68 Å2
Dissociation area: 1,231.28 Å2
Dissociation energy (ΔGdiss): -3.83 kcal/mol
Dissociation entropy (TΔSdiss): 14.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135912

Macromolecules

Kinesin-like protein KIF18A
Chain: K
Length: 377 amino acids
Theoretical weight: 42.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NI77 (Residues: 1-374; Coverage: 42%)
Gene names: KIF18A, OK/SW-cl.108
Pfam: Kinesin motor domain
InterPro:
Kinesin-like protein KIF18A in PDB entry 5ogc, assembly 1, front view.
Kinesin-like protein KIF18A in PDB entry 5ogc, assembly 1, side view.
Kinesin-like protein KIF18A in PDB entry 5ogc, assembly 1, top view.
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Tubulin alpha-1B chain
Chain: A
Length: 451 amino acids
Theoretical weight: 50.11 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-451; Coverage: 100%)
Pfam:
InterPro:
Tubulin alpha-1B chain in PDB entry 5ogc, assembly 1, front view.
Tubulin alpha-1B chain in PDB entry 5ogc, assembly 1, side view.
Tubulin alpha-1B chain in PDB entry 5ogc, assembly 1, top view.
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Tubulin beta chain
Chain: B
Length: 445 amino acids
Theoretical weight: 49.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02554 (Residues: 1-445; Coverage: 100%)
Pfam:
InterPro:
Tubulin beta chain in PDB entry 5ogc, assembly 1, front view.
Tubulin beta chain in PDB entry 5ogc, assembly 1, side view.
Tubulin beta chain in PDB entry 5ogc, assembly 1, top view.
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