Structure analysis

Crystal structure of Pig SAMHD1

X-ray diffraction
2.7Å resolution
Source organism: Sus scrofa
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 54386.85 Å2
Buried surface area: 26792.44 Å2
Dissociation area: 4,467.37 Å2
Dissociation energy (ΔGdiss): 26.29 kcal/mol
Dissociation entropy (TΔSdiss): 16.37 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-516033
Assembly 2
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Multimeric state: homo tetramer
Accessible surface area: 54532.07 Å2
Buried surface area: 26902.91 Å2
Dissociation area: 4,496.4 Å2
Dissociation energy (ΔGdiss): 31.76 kcal/mol
Dissociation entropy (TΔSdiss): 16.38 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-516033

Macromolecules

Chains: A, B, C, D, E, F, G, H
Length: 524 amino acids
Theoretical weight: 60.77 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: I3LG77 (Residues: 110-627; Coverage: 83%)
Gene name: SAMHD1
Pfam: HD domain
InterPro:

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