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Crystal structure of H5 hemagglutinin with G228S Q226L mutants from A/chicken/Taiwan/0502/2012

X-ray diffraction
2.765Å resolution
PDB entry 5yt8 coloured by chain, front view.
PDB entry 5yt8 coloured by chain, side view.
PDB entry 5yt8 coloured by chain, top view.
Source organism: Influenza A virus (A/chicken/Taiwan/0502/2012(H5N2))
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA1 chain
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Multimeric state: homo trimer
Accessible surface area: 63217.63 Å2
Buried surface area: 13158.58 Å2
Dissociation area: 6,286.22 Å2
Dissociation energy (ΔGdiss): 37.75 kcal/mol
Dissociation entropy (TΔSdiss): 32.11 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-100275

Macromolecules

Hemagglutinin HA1 chain
Chain: A
Length: 586 amino acids
Theoretical weight: 66.35 KDa
Source organism: Influenza A virus (A/chicken/Taiwan/0502/2012(H5N2))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A059VBQ9 (Residues: 15-516; Coverage: 89%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Hemagglutinin HA1 chain in PDB entry 5yt8, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 5yt8, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 5yt8, assembly 1, top view.
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