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Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260

X-ray diffraction
3.3Å resolution
PDB entry 6b0e coloured by chain, front view.
PDB entry 6b0e coloured by chain, side view.
PDB entry 6b0e coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 25 kDa ookinete surface antigen and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 27751.66 Å2
Buried surface area: 5072.3 Å2
Dissociation area: 886.88 Å2
Dissociation energy (ΔGdiss): -4.85 kcal/mol
Dissociation entropy (TΔSdiss): 12.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-230861

Macromolecules

1260 antibody, light chain
Chain: A
Length: 219 amino acids
Theoretical weight: 23.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
1260 antibody, light chain in PDB entry 6b0e, assembly 1, front view.
1260 antibody, light chain in PDB entry 6b0e, assembly 1, side view.
1260 antibody, light chain in PDB entry 6b0e, assembly 1, top view.
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1260 antibody, heavy chain
Chain: B
Length: 227 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
1260 antibody, heavy chain in PDB entry 6b0e, assembly 1, front view.
1260 antibody, heavy chain in PDB entry 6b0e, assembly 1, side view.
1260 antibody, heavy chain in PDB entry 6b0e, assembly 1, top view.
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25 kDa ookinete surface antigen
Chain: E
Length: 183 amino acids
Theoretical weight: 20.1 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Homo sapiens
UniProt:
  • Canonical: P13829 (Residues: 22-193; Coverage: 86%)
Pfam: Pvs28 EGF domain
InterPro:
CATH: Plasmodium vivax P25 domain
25 kDa ookinete surface antigen in PDB entry 6b0e, assembly 1, front view.
25 kDa ookinete surface antigen in PDB entry 6b0e, assembly 1, side view.
25 kDa ookinete surface antigen in PDB entry 6b0e, assembly 1, top view.
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