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Crystal Structure of Human Argonaute2 Bound to Three Tryptophans

X-ray diffraction
2.203Å resolution
PDB entry 6cbd coloured by chain, front view.
PDB entry 6cbd coloured by chain, side view.
PDB entry 6cbd coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein argonaute-2 and RNA
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Multimeric state: hetero trimer
Accessible surface area: 36311.8 Å2
Buried surface area: 8445.39 Å2
Dissociation area: 1,613.04 Å2
Dissociation energy (ΔGdiss): 4.72 kcal/mol
Dissociation entropy (TΔSdiss): 10.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193885

Macromolecules

Protein argonaute-2
Chain: A
Length: 859 amino acids
Theoretical weight: 97.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UKV8 (Residues: 1-859; Coverage: 100%)
Gene names: AGO2, EIF2C2
Pfam:
InterPro:
CATH:
Protein argonaute-2 in PDB entry 6cbd, assembly 1, front view.
Protein argonaute-2 in PDB entry 6cbd, assembly 1, side view.
Protein argonaute-2 in PDB entry 6cbd, assembly 1, top view.
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RNA chain B
Name: Guide RNA
Representative chains: B
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.55 KDa
Guide RNA in PDB entry 6cbd, assembly 1, front view.
Guide RNA in PDB entry 6cbd, assembly 1, side view.
Guide RNA in PDB entry 6cbd, assembly 1, top view.
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RNA chain C
Name: Target RNA
Representative chains: C
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 11 nucleotides
Theoretical weight: 3.54 KDa
Target RNA in PDB entry 6cbd, assembly 1, front view.
Target RNA in PDB entry 6cbd, assembly 1, side view.
Target RNA in PDB entry 6cbd, assembly 1, top view.
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