PDB 6euy biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1

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Assembly Name: Polymerase basic protein 2
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Multimeric state: monomeric

Accessible surface area: 13494.01 Å²

Buried surface area: 627.82 Å²

Dissociation area: 61.16 Å²

Dissociation energy (ΔG^diss): 7.81 kcal/mol

Dissociation entropy (TΔS^diss): 0.58 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-151984

$Monomeric assembly 1 of PDB entry 6euy coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>4 copies of SULFATE ION.</li></ul>}$

$Monomeric assembly 1 of PDB entry 6euy coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>4 copies of SULFATE ION.</li></ul>}$

$Monomeric assembly 1 of PDB entry 6euy coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>4 copies of SULFATE ION.</li></ul>}$

Assembly 2

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Assembly Name: Polymerase basic protein 2
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Multimeric state: monomeric

Accessible surface area: 13170.45 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-151984

$Monomeric assembly 2 of PDB entry 6euy coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 2 of PDB entry 6euy coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid.</li></ul>}$

$Monomeric assembly 2 of PDB entry 6euy coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid.</li></ul>}$

Assembly 3 (preferred)

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Assembly Name: Polymerase basic protein 2
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Multimeric state: monomeric

Accessible surface area: 13947.88 Å²

Buried surface area: 379.93 Å²

Dissociation area: 92.24 Å²

Dissociation energy (ΔG^diss): 12.35 kcal/mol

Dissociation entropy (TΔS^diss): 0.59 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-151984

$Monomeric assembly 3 of PDB entry 6euy coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>2 copies of SULFATE ION.</li></ul>}$

$Monomeric assembly 3 of PDB entry 6euy coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>2 copies of SULFATE ION.</li></ul>}$

$Monomeric assembly 3 of PDB entry 6euy coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Polymerase basic protein 2;</li> <li class='image_legend_li'>1 copy of (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid;</li> <li class='image_legend_li'>2 copies of SULFATE ION.</li></ul>}$

Macromolecules

Polymerase basic protein 2

Chains: A, B, C
Length: 290 amino acids
Theoretical weight: 32.52 KDa
Source organism: Influenza A virus (A/Victoria/3/1975(H3N2))
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P31345 (Residues: 247-536; Coverage: 38%)

Gene name: PB2
Pfam:

Influenza RNA polymerase PB2 helical domain
Influenza RNA polymerase PB2 CAP binding domain

InterPro: Influenza RNA-dependent RNA polymerase subunit PB2

Polymerase basic protein 2 in PDB entry 6euy, assembly 3, front view.

Polymerase basic protein 2 in PDB entry 6euy, assembly 3, side view.

Polymerase basic protein 2 in PDB entry 6euy, assembly 3, top view.

FASTA Sequence


    >pdb|6euy|A B C

GGEVRNDDIDQSLIIAARNIVRRASVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETHGTERLTITYSSSMM

PDBe-KB: UniProt Coverage View: P31345

Molecule details ›

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FASTA (Protein chains A, B, C)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P31345 (UniProt)

Protein Data Bank in Europe

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

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Assemblies

Assembly 1

Assembly 2

Assembly 3 (preferred)

Macromolecules

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PDBe › 6euy › Structure analysis

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

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Assemblies

Assembly 1

Assembly 2

Assembly 3 (preferred)

Macromolecules

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6euy › Structure analysis