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Solution Structure of CaM/Kv7.2-hAB Complex

Solution NMR
PDB entry 6feh coloured by chain, ensemble of 10 models, front view.
PDB entry 6feh coloured by chain, ensemble of 10 models, side view.
PDB entry 6feh coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Calmodulin-1 and Potassium voltage-gated channel subfamily KQT member 2
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Multimeric state: hetero dimer
Accessible surface area: 19154.57 Å2
Buried surface area: 4117.03 Å2
Dissociation area: 1,929.74 Å2
Dissociation energy (ΔGdiss): 30.01 kcal/mol
Dissociation entropy (TΔSdiss): 12.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128987

Macromolecules

Potassium voltage-gated channel subfamily KQT member 2
Chain: A
Length: 115 amino acids
Theoretical weight: 13.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43526 (Residues: 326-372, 530-560; Coverage: 9%)
Gene name: KCNQ2
InterPro:
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 6feh, assembly 1, front view.
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 6feh, assembly 1, side view.
Potassium voltage-gated channel subfamily KQT member 2 in PDB entry 6feh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O43526  
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Calmodulin-1
Chain: B
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Pfam: EF-hand domain pair
InterPro:
Calmodulin-1 in PDB entry 6feh, assembly 1, front view.
Calmodulin-1 in PDB entry 6feh, assembly 1, side view.
Calmodulin-1 in PDB entry 6feh, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P0DP23  
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