› › Structure analysis

CDK1/CyclinB/Cks2 in complex with CGP74514A

X-ray diffraction
2.73Å resolution
PDB entry 6gu4 coloured by chain, front view.
PDB entry 6gu4 coloured by chain, side view.
PDB entry 6gu4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin B1-CDK1 complex and Cyclin-dependent kinases regulatory subunit
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Multimeric state: hetero trimer
Accessible surface area: 28113.58 Å2
Buried surface area: 4282.12 Å2
Dissociation area: 711.22 Å2
Dissociation energy (ΔGdiss): -0.46 kcal/mol
Dissociation entropy (TΔSdiss): 11.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-125641

Macromolecules

Cyclin-dependent kinase 1
Chain: A
Length: 302 amino acids
Theoretical weight: 34.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06493 (Residues: 1-297; Coverage: 100%)
Gene names: CDC2, CDC28A, CDK1, CDKN1, P34CDC2
Pfam: Protein kinase domain
InterPro:
CATH:
Cyclin-dependent kinase 1 in PDB entry 6gu4, assembly 1, front view.
Cyclin-dependent kinase 1 in PDB entry 6gu4, assembly 1, side view.
Cyclin-dependent kinase 1 in PDB entry 6gu4, assembly 1, top view.
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G2/mitotic-specific cyclin-B1
Chain: B
Length: 273 amino acids
Theoretical weight: 31.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14635 (Residues: 165-433; Coverage: 62%)
Gene names: CCNB, CCNB1
Pfam:
InterPro:
CATH: Cyclin-like
G2/mitotic-specific cyclin-B1 in PDB entry 6gu4, assembly 1, front view.
G2/mitotic-specific cyclin-B1 in PDB entry 6gu4, assembly 1, side view.
G2/mitotic-specific cyclin-B1 in PDB entry 6gu4, assembly 1, top view.
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Cyclin-dependent kinases regulatory subunit
Chain: C
Length: 84 amino acids
Theoretical weight: 10.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: K9J4F7 (Residues: 11-89; Coverage: 89%)
Pfam: Cyclin-dependent kinase regulatory subunit
InterPro:
CATH: Cyclin-dependent kinase, regulatory subunit
Cyclin-dependent kinases regulatory subunit in PDB entry 6gu4, assembly 1, front view.
Cyclin-dependent kinases regulatory subunit in PDB entry 6gu4, assembly 1, side view.
Cyclin-dependent kinases regulatory subunit in PDB entry 6gu4, assembly 1, top view.
Molecule details ›

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