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cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.

Source organism: Homo sapiens
Biochemical function: sterol binding
Biological process: SREBP signaling pathway
Cellular component: endoplasmic reticulum membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF12349
Domain description: Sterol-sensing domain of SREBP cleavage-activation
Occurring in:
  1. Sterol regulatory element-binding protein cleavage-activating protein
The deposited structure of PDB entry 6m49 contains 1 copy of Pfam domain PF12349 (Sterol-sensing domain of SREBP cleavage-activation) in Sterol regulatory element-binding protein cleavage-activating protein. Showing 1 copy in chain B.

PF07281
Domain description: Insulin-induced protein (INSIG)
Occurring in:
  1. Insulin-induced gene 2 protein
The deposited structure of PDB entry 6m49 contains 1 copy of Pfam domain PF07281 (Insulin-induced protein (INSIG)) in Insulin-induced gene 2 protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000731
Domain description: Sterol-sensing domain
Occurring in:
  1. Sterol regulatory element-binding protein cleavage-activating protein
IPR025929
Domain description: Insulin-induced protein family
Occurring in:
  1. Insulin-induced gene 2 protein
IPR030225
Domain description: Sterol regulatory element-binding protein cleavage-activating protein
Occurring in:
  1. Sterol regulatory element-binding protein cleavage-activating protein

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