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cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.

Electron Microscopy
3.7Å resolution
PDB entry 6m49 coloured by chain, front view.
PDB entry 6m49 coloured by chain, side view.
PDB entry 6m49 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sterol regulatory element-binding protein cleavage-activating protein and Insulin-induced gene 2 protein
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Multimeric state: hetero dimer
Accessible surface area: 23522.61 Å2
Buried surface area: 3177.87 Å2
Dissociation area: 1,314.36 Å2
Dissociation energy (ΔGdiss): 6.7 kcal/mol
Dissociation entropy (TΔSdiss): 12.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171390

Macromolecules

Insulin-induced gene 2 protein
Chain: A
Length: 225 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5U4 (Residues: 1-225; Coverage: 100%)
Gene name: INSIG2
Pfam: Insulin-induced protein (INSIG)
InterPro: Insulin-induced protein family
Insulin-induced gene 2 protein in PDB entry 6m49, assembly 1, front view.
Insulin-induced gene 2 protein in PDB entry 6m49, assembly 1, side view.
Insulin-induced gene 2 protein in PDB entry 6m49, assembly 1, top view.
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Sterol regulatory element-binding protein cleavage-activating protein
Chain: B
Length: 572 amino acids
Theoretical weight: 63.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12770 (Residues: 1-735; Coverage: 45%)
  • Best match: Q12770-4 (Residues: 1-343)
Gene names: KIAA0199, PSEC0227, SCAP
Pfam: Sterol-sensing domain of SREBP cleavage-activation
InterPro:
Sterol regulatory element-binding protein cleavage-activating protein in PDB entry 6m49, assembly 1, front view.
Sterol regulatory element-binding protein cleavage-activating protein in PDB entry 6m49, assembly 1, side view.
Sterol regulatory element-binding protein cleavage-activating protein in PDB entry 6m49, assembly 1, top view.
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