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human cGAS catalytic domain bound with the inhibitor G108

X-ray diffraction
2.45Å resolution
PDB entry 6mju coloured by chain, front view.
PDB entry 6mju coloured by chain, side view.
PDB entry 6mju coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclic GMP-AMP synthase
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Multimeric state: monomeric
Accessible surface area: 16922.01 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185433

Macromolecules

Cyclic GMP-AMP synthase
Chain: A
Length: 372 amino acids
Theoretical weight: 43.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N884 (Residues: 152-522; Coverage: 71%)
Gene names: C6orf150, CGAS, MB21D1
Pfam:
InterPro:
CATH:
Cyclic GMP-AMP synthase in PDB entry 6mju, assembly 1, front view.
Cyclic GMP-AMP synthase in PDB entry 6mju, assembly 1, side view.
Cyclic GMP-AMP synthase in PDB entry 6mju, assembly 1, top view.
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