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Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60

X-ray diffraction
2.8Å resolution
PDB entry 6pd9 coloured by chain, front view.
PDB entry 6pd9 coloured by chain, side view.
PDB entry 6pd9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone acetyltransferase KAT8
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Multimeric state: monomeric
Accessible surface area: 13733.76 Å2
Buried surface area: 665.55 Å2
Dissociation area: 94.33 Å2
Dissociation energy (ΔGdiss): -0.56 kcal/mol
Dissociation entropy (TΔSdiss): 0.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190669

Macromolecules

Histone acetyltransferase KAT8
Chain: A
Length: 272 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 177-448; Coverage: 59%)
Gene names: KAT8, MOF, MYST1, PP7073
Pfam:
InterPro:
Histone acetyltransferase KAT8 in PDB entry 6pd9, assembly 1, front view.
Histone acetyltransferase KAT8 in PDB entry 6pd9, assembly 1, side view.
Histone acetyltransferase KAT8 in PDB entry 6pd9, assembly 1, top view.
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