Function and Biology Details
Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- NADH-quinone oxidoreductase subunit E-like
- 4Fe-4S ferredoxin-type, iron-sulphur binding domain
- NADH-quinone oxidoreductase, chain I
- NADH-ubiquinone oxidoreductase, 20 Kd subunit
- NAD(P)H-quinone oxidoreductase subunit D/H
- NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
- NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
- Acyl carrier protein
44 more domains
Structure analysis Details
Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-167317 (preferred)
Entry contents:
18 distinct polypeptide molecules
Macromolecules (18 distinct):
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Molecule details ›
Chain: V1
Length: 445 amino acids
Theoretical weight: 48.68 KDa
Source organism: Ovis aries
UniProt:
Sequence domains:
Length: 445 amino acids
Theoretical weight: 48.68 KDa
Source organism: Ovis aries
UniProt:
- Canonical:
W5PUX0 (Residues: 20-464; Coverage: 96%)
Sequence domains:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Molecule details ›
Chain: V2
Length: 217 amino acids
Theoretical weight: 23.84 KDa
Source organism: Ovis aries
UniProt:
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
Length: 217 amino acids
Theoretical weight: 23.84 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5NRY1 (Residues: 30-246; Coverage: 88%)
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Molecule details ›
Chain: S3
Length: 228 amino acids
Theoretical weight: 26.44 KDa
Source organism: Ovis aries
UniProt:
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Length: 228 amino acids
Theoretical weight: 26.44 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5PB27 (Residues: 39-266; Coverage: 86%)
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Molecule details ›
Chain: S4
Length: 133 amino acids
Theoretical weight: 15.38 KDa
Source organism: Ovis aries
UniProt:
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
Length: 133 amino acids
Theoretical weight: 15.38 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5PE07 (Residues: 38-170; Coverage: 78%)
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Molecule details ›
Chain: A6
Length: 127 amino acids
Theoretical weight: 14.92 KDa
Source organism: Ovis aries
UniProt:
Sequence domains: Complex 1 protein (LYR family)
Length: 127 amino acids
Theoretical weight: 14.92 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5QC06 (Residues: 14-140; Coverage: 91%)
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Molecule details ›
Chain: A7
Length: 112 amino acids
Theoretical weight: 12.4 KDa
Source organism: Ovis aries
UniProt:
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Length: 112 amino acids
Theoretical weight: 12.4 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5P0I2 (Residues: 3-114; Coverage: 98%)
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Acyl carrier protein
Molecule details ›
Chain: AA
Length: 88 amino acids
Theoretical weight: 10.12 KDa
Source organism: Ovis aries
UniProt:
Length: 88 amino acids
Theoretical weight: 10.12 KDa
Source organism: Ovis aries
UniProt:
- Canonical: W5NQT7 (Residues: 70-157; Coverage: 56%)
