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cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: cellular response to nutrient levels
Cellular component: cytosol

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EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Target of rapamycin complex subunit LST8
  2. Regulatory-associated protein of mTOR

PF02985
Domain description: HEAT repeat
Occurring in:
  1. Regulatory-associated protein of mTOR

PF04670
Domain description: Gtr1/RagA G protein conserved region
Occurring in:
  1. Ras-related GTP-binding protein A
  2. Ras-related GTP-binding protein C

PF15798
Domain description: Proline-rich AKT1 substrate 1
Occurring in:
  1. Proline-rich AKT1 substrate 1

PF22911
Domain description: Proline-rich AKT1 substrate 1, N-terminal domain
Occurring in:
  1. Proline-rich AKT1 substrate 1

PF14538
Domain description: Raptor N-terminal CASPase like domain
Occurring in:
  1. Regulatory-associated protein of mTOR

PF02260
Domain description: FATC domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR

PF00454
Domain description: Phosphatidylinositol 3- and 4-kinase
Occurring in:
  1. Serine/threonine-protein kinase mTOR

PF08771
Domain description: FKBP12-rapamycin binding domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR

PF02259
Domain description: FAT domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR

PF11865
Domain description: Serine/threonine-protein kinase mTOR domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Target of rapamycin complex subunit LST8
  2. Regulatory-associated protein of mTOR
IPR006762
Domain description: Gtr1/RagA G protein
Occurring in:
  1. Ras-related GTP-binding protein A
  2. Ras-related GTP-binding protein C
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related GTP-binding protein A
  2. Ras-related GTP-binding protein C
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Serine/threonine-protein kinase mTOR
  2. Regulatory-associated protein of mTOR
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Target of rapamycin complex subunit LST8
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Target of rapamycin complex subunit LST8
  2. Regulatory-associated protein of mTOR
IPR000403
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR026682
Domain description: Proline-rich AKT1 substrate 1 protein
Occurring in:
  1. Proline-rich AKT1 substrate 1
IPR029347
Domain description: Raptor, N-terminal CASPase-like domain
Occurring in:
  1. Regulatory-associated protein of mTOR
IPR003152
Domain description: FATC domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR018936
Domain description: Phosphatidylinositol 3/4-kinase, conserved site
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR036738
Domain description: FKBP12-rapamycin binding domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Serine/threonine-protein kinase mTOR
  2. Regulatory-associated protein of mTOR
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Regulatory-associated protein of mTOR
IPR000357
Domain description: HEAT repeat
Occurring in:
  1. Regulatory-associated protein of mTOR
IPR004083
Domain description: Regulatory associated protein of TOR
Occurring in:
  1. Regulatory-associated protein of mTOR
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Target of rapamycin complex subunit LST8
IPR011047
Domain description: Quinoprotein alcohol dehydrogenase-like superfamily
Occurring in:
  1. Target of rapamycin complex subunit LST8
IPR037588
Domain description: Target of rapamycin complex subunit LST8
Occurring in:
  1. Target of rapamycin complex subunit LST8
IPR039400
Domain description: RagC/D
Occurring in:
  1. Ras-related GTP-binding protein C
IPR039397
Domain description: RagA/B
Occurring in:
  1. Ras-related GTP-binding protein A
IPR036940
Domain description: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR026683
Domain description: Serine/threonine-protein kinase TOR, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR009076
Domain description: FKBP12-rapamycin binding domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR003151
Domain description: PIK-related kinase, FAT
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR014009
Domain description: PIK-related kinase
Occurring in:
  1. Serine/threonine-protein kinase mTOR
IPR024585
Domain description: Serine/threonine-protein kinase mTOR domain
Occurring in:
  1. Serine/threonine-protein kinase mTOR

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