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cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases

Electron Microscopy
5.5Å resolution
PDB entry 6sb0 coloured by chain, front view.
PDB entry 6sb0 coloured by chain, side view.
PDB entry 6sb0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: mTORC1 complex
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Multimeric state: hetero dodecamer
PDBe Complex ID: PDB-CPX-154634

Macromolecules

Serine/threonine-protein kinase mTOR
Chains: A, B
Length: 2549 amino acids
Theoretical weight: 287.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42345 (Residues: 60-2549; Coverage: 98%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam:
InterPro:
Serine/threonine-protein kinase mTOR in PDB entry 6sb0, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 6sb0, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 6sb0, assembly 1, top view.
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Target of rapamycin complex subunit LST8
Chains: E, H
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-326; Coverage: 100%)
Gene names: GBL, LST8, MLST8
Pfam: WD domain, G-beta repeat
InterPro:
Target of rapamycin complex subunit LST8 in PDB entry 6sb0, assembly 1, front view.
Target of rapamycin complex subunit LST8 in PDB entry 6sb0, assembly 1, side view.
Target of rapamycin complex subunit LST8 in PDB entry 6sb0, assembly 1, top view.
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Ras-related GTP-binding protein A
Chains: C, I
Length: 313 amino acids
Theoretical weight: 36.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L523 (Residues: 1-313; Coverage: 100%)
Gene name: RRAGA
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Ras-related GTP-binding protein A in PDB entry 6sb0, assembly 1, front view.
Ras-related GTP-binding protein A in PDB entry 6sb0, assembly 1, side view.
Ras-related GTP-binding protein A in PDB entry 6sb0, assembly 1, top view.
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Ras-related GTP-binding protein C
Chains: D, J
Length: 399 amino acids
Theoretical weight: 44.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HB90 (Residues: 1-399; Coverage: 100%)
Gene name: RRAGC
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Ras-related GTP-binding protein C in PDB entry 6sb0, assembly 1, front view.
Ras-related GTP-binding protein C in PDB entry 6sb0, assembly 1, side view.
Ras-related GTP-binding protein C in PDB entry 6sb0, assembly 1, top view.
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Regulatory-associated protein of mTOR
Chains: N, Y
Length: 1335 amino acids
Theoretical weight: 149.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N122 (Residues: 1-1335; Coverage: 100%)
Gene names: KIAA1303, RAPTOR, RPTOR
Pfam:
InterPro:
Regulatory-associated protein of mTOR in PDB entry 6sb0, assembly 1, front view.
Regulatory-associated protein of mTOR in PDB entry 6sb0, assembly 1, side view.
Regulatory-associated protein of mTOR in PDB entry 6sb0, assembly 1, top view.
Molecule details ›

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Proline-rich AKT1 substrate 1
Chains: O, T
Length: 256 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96B36 (Residues: 1-256; Coverage: 100%)
Gene names: AKT1S1, PRAS40
Pfam:
InterPro: Proline-rich AKT1 substrate 1 protein
Proline-rich AKT1 substrate 1 in PDB entry 6sb0, assembly 1, front view.
Proline-rich AKT1 substrate 1 in PDB entry 6sb0, assembly 1, side view.
Proline-rich AKT1 substrate 1 in PDB entry 6sb0, assembly 1, top view.
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