Assemblies
Assembly Name:
mTORC1 complex
Multimeric state:
hetero dodecamer
PDBe Complex ID:
PDB-CPX-154634
Macromolecules
Chains: A, B
Length: 2549 amino acids
Theoretical weight: 287.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
Length: 2549 amino acids
Theoretical weight: 287.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P42345 (Residues: 60-2549; Coverage: 98%)
Pfam:
- Serine/threonine-protein kinase mTOR domain
- FAT domain
- FKBP12-rapamycin binding domain
- Phosphatidylinositol 3- and 4-kinase
- FATC domain
- Armadillo-like helical
- Armadillo-type fold
- Serine/threonine-protein kinase mTOR domain
- PIK-related kinase
- Tetratricopeptide-like helical domain superfamily
- PIK-related kinase, FAT
- FKBP12-rapamycin binding domain
- FKBP12-rapamycin binding domain superfamily
- Protein kinase-like domain superfamily
- Serine/threonine-protein kinase TOR, catalytic domain
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphatidylinositol 3/4-kinase, conserved site
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- FATC domain
Chains: E, H
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: WD domain, G-beta repeat
InterPro:
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9BVC4 (Residues: 1-326; Coverage: 100%)
Pfam: WD domain, G-beta repeat
InterPro:
Chains: C, I
Length: 313 amino acids
Theoretical weight: 36.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Length: 313 amino acids
Theoretical weight: 36.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q7L523 (Residues: 1-313; Coverage: 100%)
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Chains: D, J
Length: 399 amino acids
Theoretical weight: 44.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Length: 399 amino acids
Theoretical weight: 44.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9HB90 (Residues: 1-399; Coverage: 100%)
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Chains: N, Y
Length: 1335 amino acids
Theoretical weight: 149.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 1335 amino acids
Theoretical weight: 149.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q8N122 (Residues: 1-1335; Coverage: 100%)
Pfam:
InterPro:
Chains: O, T
Length: 256 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam:
InterPro: Proline-rich AKT1 substrate 1 protein
Length: 256 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q96B36 (Residues: 1-256; Coverage: 100%)
Pfam:
InterPro: Proline-rich AKT1 substrate 1 protein