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Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

Herfst S, Zhang J, Richard M, McBride R, Lexmond P, Bestebroer TM, Spronken MIJ, de Meulder D, van den Brand JM, Rosu ME, Martin SR, Gamblin SJ, Xiong X, Peng W, Bodewes R, van der Vries E, Osterhaus ADME, Paulson JC, Skehel JJ, Fouchier RAM
Cell Host Microbe 28 602-613.e7 (2020)
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Cited: 12 times
EuropePMC logo PMID: 33031770

Abstract

In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that increase stability and receptor binding. The seal A/H10N7 virus was aerosol or respiratory droplet transmissible between ferrets. Compared with avian H10 hemagglutinin, seal H10 hemagglutinin showed stronger binding to the human-type sialic acid receptor, with preferential binding to α2,6-linked sialic acids on long extended branches. In X-ray structures, changes in the 220-loop of the receptor-binding pocket caused similar interactions with human receptor as seen for pandemic strains. Two substitutions made seal H10 hemagglutinin more stable than avian H10 hemagglutinin and similar to human hemagglutinin. Consequently, identification of avian-origin influenza viruses across mammals appears critical to detect influenza A viruses posing a major threat to humans and other mammals.

Articles - 6tjw mentioned but not cited (1)

  1. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Herfst S, Zhang J, Richard M, McBride R, Lexmond P, Bestebroer TM, Spronken MIJ, de Meulder D, van den Brand JM, Rosu ME, Martin SR, Gamblin SJ, Xiong X, Peng W, Bodewes R, van der Vries E, Osterhaus ADME, Paulson JC, Skehel JJ, Fouchier RAM. Cell Host Microbe 28 602-613.e7 (2020)


Reviews citing this publication (5)

  1. Hemagglutinin Stability and Its Impact on Influenza A Virus Infectivity, Pathogenicity, and Transmissibility in Avians, Mice, Swine, Seals, Ferrets, and Humans. Russell CJ. Viruses 13 746 (2021)
  2. Animal Models for Influenza Research: Strengths and Weaknesses. Nguyen TQ, Rollon R, Choi YK. Viruses 13 1011 (2021)
  3. Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges. Terrier O, Si-Tahar M, Ducatez M, Chevalier C, Pizzorno A, Le Goffic R, Crépin T, Simon G, Naffakh N. PLoS Pathog 17 e1010106 (2021)
  4. Immune Control of Avian Influenza Virus Infection and Its Vaccine Development. Dey P, Ahuja A, Panwar J, Choudhary P, Rani S, Kaur M, Sharma A, Kaur J, Yadav AK, Sood V, Suresh Babu AR, Bhadada SK, Singh G, Barnwal RP. Vaccines (Basel) 11 593 (2023)
  5. Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts. Abdelwhab EM, Mettenleiter TC. Viruses 15 980 (2023)

Articles citing this publication (6)

  1. Congress COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment - Meeting report from an isirv-WHO virtual conference. McKimm-Breschkin JL, Hay AJ, Cao B, Cox RJ, Dunning J, Moen AC, Olson D, Pizzorno A, Hayden FG. Antiviral Res 197 105227 (2022)
  2. We need to keep an eye on avian influenza. Krammer F, Schultz-Cherry S. Nat Rev Immunol 23 267-268 (2023)
  3. The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections. Everest H, Billington E, Daines R, Burman A, Iqbal M. mBio 12 e0178521 (2021)
  4. Recipe for Zoonosis: How Influenza Virus Leaps into Human Circulation. Honce R, Schultz-Cherry S. Cell Host Microbe 28 506-508 (2020)
  5. Swine H1N1 Influenza Virus Variants with Enhanced Polymerase Activity and HA Stability Promote Airborne Transmission in Ferrets. Hu M, Jones JC, Banoth B, Ojha CR, Crumpton JC, Kercher L, Webster RG, Webby RJ, Russell CJ. J Virol 96 e0010022 (2022)
  6. Field Research Is Essential to Counter Virological Threats. Runstadler JA, Lowen AC, Kayali G, Tompkins SM, Albrecht RA, Fouchier RAM, Stallknecht DE, Lakdawala SS, Goodrum FD, Casadevall A, Enquist LW, Alwine JC, Imperiale MJ, Schultz-Cherry S, Webby RJ. J Virol 97 e0054423 (2023)


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