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Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc.

Electron Microscopy
3.3Å resolution
PDB entry 6tko coloured by chain, front view.
PDB entry 6tko coloured by chain, side view.
PDB entry 6tko coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 46370.14 Å2
Buried surface area: 9399.32 Å2
Dissociation area: 825.05 Å2
Dissociation energy (ΔGdiss): 0.02 kcal/mol
Dissociation entropy (TΔSdiss): 14.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279540

Macromolecules

Beta-1 adrenergic receptor
Chain: A
Length: 328 amino acids
Theoretical weight: 37.28 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 32-357; Coverage: 62%)
Gene name: ADRB1
Pfam: 7 transmembrane receptor (rhodopsin family)
InterPro:
Beta-1 adrenergic receptor in PDB entry 6tko, assembly 1, front view.
Beta-1 adrenergic receptor in PDB entry 6tko, assembly 1, side view.
Beta-1 adrenergic receptor in PDB entry 6tko, assembly 1, top view.
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Beta-arrestin-1
Chain: B
Length: 418 amino acids
Theoretical weight: 47.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49407 (Residues: 1-418; Coverage: 100%)
Gene names: ARR1, ARRB1
Pfam:
InterPro:
Beta-arrestin-1 in PDB entry 6tko, assembly 1, front view.
Beta-arrestin-1 in PDB entry 6tko, assembly 1, side view.
Beta-arrestin-1 in PDB entry 6tko, assembly 1, top view.
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Fab30 heavy chain
Chain: H
Length: 237 amino acids
Theoretical weight: 25.51 KDa
Source organism: Phage display vector pTDisp
Expression system: Escherichia coli
InterPro:
Fab30 heavy chain in PDB entry 6tko, assembly 1, front view.
Fab30 heavy chain in PDB entry 6tko, assembly 1, side view.
Fab30 heavy chain in PDB entry 6tko, assembly 1, top view.
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Fab30 light chain
Chain: L
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: Phage display vector pTDisp
Expression system: Escherichia coli
InterPro:
Fab30 light chain in PDB entry 6tko, assembly 1, front view.
Fab30 light chain in PDB entry 6tko, assembly 1, side view.
Fab30 light chain in PDB entry 6tko, assembly 1, top view.
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