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Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env

Electron Microscopy
4.2Å resolution
PDB entry 6um5 coloured by chain, front view.
PDB entry 6um5 coloured by chain, side view.
PDB entry 6um5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dodecamer
Accessible surface area: 127090.65 Å2
Buried surface area: 53769.96 Å2
Dissociation area: 3,666.18 Å2
Dissociation energy (ΔGdiss): -54.91 kcal/mol
Dissociation entropy (TΔSdiss): 41.85 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-207411

Macromolecules

Envelope glycoprotein gp160
Chains: A, E, I
Length: 462 amino acids
Theoretical weight: 51.69 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1W6IPB2 (Residues: 30-489; Coverage: 54%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
Envelope glycoprotein gp160 in PDB entry 6um5, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 6um5, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 6um5, assembly 1, top view.
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Transmembrane protein gp41
Chains: B, F, J
Length: 153 amino acids
Theoretical weight: 17.16 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S7 (Residues: 509-661; Coverage: 18%)
Gene name: env
Pfam: Retroviral envelope protein
InterPro: Retroviral envelope protein GP41-like
Transmembrane protein gp41 in PDB entry 6um5, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 6um5, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 6um5, assembly 1, top view.
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DH270 UCA3 Fab Heavy Chain
Chains: C, G, K
Length: 238 amino acids
Theoretical weight: 25.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
DH270 UCA3 Fab Heavy Chain in PDB entry 6um5, assembly 1, front view.
DH270 UCA3 Fab Heavy Chain in PDB entry 6um5, assembly 1, side view.
DH270 UCA3 Fab Heavy Chain in PDB entry 6um5, assembly 1, top view.
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DH270 UCA3 Fab Light Chain
Chains: D, H, L
Length: 216 amino acids
Theoretical weight: 22.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
DH270 UCA3 Fab Light Chain in PDB entry 6um5, assembly 1, front view.
DH270 UCA3 Fab Light Chain in PDB entry 6um5, assembly 1, side view.
DH270 UCA3 Fab Light Chain in PDB entry 6um5, assembly 1, top view.
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