6vrl

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-207333 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium-dependent serotonin transporter Chain: A
Molecule details ›
Chain: A
Length: 630 amino acids
Theoretical weight: 70.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31645 (Residues: 1-630; Coverage: 100%)
Gene names: HTT, SERT, SLC6A4
Sequence domains:
Ig-like domain-containing protein Chain: C
Molecule details ›
Chain: C
Length: 214 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A0U5BC76 (Residues: 21-234; Coverage: 100%)
Gene name: LC
Sequence domains:
8B6 antibody, heavy chain Chain: B
Molecule details ›
Chain: B
Length: 221 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-21370
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda