› › Structure analysis

Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab

Electron Microscopy
3.8Å resolution
PDB entry 6vrl coloured by chain, front view.
PDB entry 6vrl coloured by chain, side view.
PDB entry 6vrl coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 31635.57 Å2
Buried surface area: 4827.01 Å2
Dissociation area: 1,734.28 Å2
Dissociation energy (ΔGdiss): -10.36 kcal/mol
Dissociation entropy (TΔSdiss): 24.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207333

Macromolecules

Sodium-dependent serotonin transporter
Chain: A
Length: 630 amino acids
Theoretical weight: 70.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31645 (Residues: 1-630; Coverage: 100%)
Gene names: HTT, SERT, SLC6A4
Pfam:
InterPro:
Sodium-dependent serotonin transporter in PDB entry 6vrl, assembly 1, front view.
Sodium-dependent serotonin transporter in PDB entry 6vrl, assembly 1, side view.
Sodium-dependent serotonin transporter in PDB entry 6vrl, assembly 1, top view.
Molecule details ›

Search similar proteins

Ig-like domain-containing protein
Chain: C
Length: 214 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A0U5BC76 (Residues: 21-234; Coverage: 100%)
Gene name: LC
Pfam:
InterPro:
Ig-like domain-containing protein in PDB entry 6vrl, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 6vrl, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 6vrl, assembly 1, top view.
Molecule details ›

Search similar proteins

8B6 antibody, heavy chain
Chain: B
Length: 221 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
InterPro:
8B6 antibody, heavy chain in PDB entry 6vrl, assembly 1, front view.
8B6 antibody, heavy chain in PDB entry 6vrl, assembly 1, side view.
8B6 antibody, heavy chain in PDB entry 6vrl, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links