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Human secretin receptor Gs complex

Electron Microscopy
4.3Å resolution
PDB entry 6wi9 coloured by chain, front view.
PDB entry 6wi9 coloured by chain, side view.
PDB entry 6wi9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 52819.88 Å2
Buried surface area: 15466.23 Å2
Dissociation area: 1,335.47 Å2
Dissociation energy (ΔGdiss): -0.74 kcal/mol
Dissociation entropy (TΔSdiss): 12.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209416

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63092 (Residues: 1-394; Coverage: 100%)
  • Best match: P63092-4 (Residues: 1-395)
Gene names: GNAS, GNAS1, GSP
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6wi9, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6wi9, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 6wi9, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6wi9, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6wi9, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 6wi9, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6wi9, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6wi9, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 6wi9, assembly 1, top view.
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Nanobody35
Chain: N
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
Nanobody35 in PDB entry 6wi9, assembly 1, front view.
Nanobody35 in PDB entry 6wi9, assembly 1, side view.
Nanobody35 in PDB entry 6wi9, assembly 1, top view.
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Secretin
Chain: P
Length: 27 amino acids
Theoretical weight: 3.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09683 (Residues: 28-54; Coverage: 26%)
Gene name: SCT
Pfam: Peptide hormone
InterPro:
Secretin in PDB entry 6wi9, assembly 1, front view.
Secretin in PDB entry 6wi9, assembly 1, side view.
Secretin in PDB entry 6wi9, assembly 1, top view.
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Secretin receptor
Chain: R
Length: 453 amino acids
Theoretical weight: 51.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P47872 (Residues: 22-440; Coverage: 100%)
Gene name: SCTR
Pfam:
InterPro:
Secretin receptor in PDB entry 6wi9, assembly 1, front view.
Secretin receptor in PDB entry 6wi9, assembly 1, side view.
Secretin receptor in PDB entry 6wi9, assembly 1, top view.
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