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Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters

X-ray diffraction
3.5Å resolution
PDB entry 6wk5 coloured by chain, front view.
PDB entry 6wk5 coloured by chain, side view.
PDB entry 6wk5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Multidrug resistance protein, SMR family
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Multimeric state: hetero tetramer
Accessible surface area: 19760.42 Å2
Buried surface area: 4209.53 Å2
Dissociation area: 764.95 Å2
Dissociation energy (ΔGdiss): -5.94 kcal/mol
Dissociation entropy (TΔSdiss): 22.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-167719

Macromolecules

Multidrug resistance protein, SMR family
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.53 KDa
Source organism: Clostridiales bacterium oral taxon 876 str. F0540
Expression system: Escherichia coli
UniProt:
  • Canonical: U2EQ00 (Residues: 1-105; Coverage: 100%)
Gene name: HMPREF1982_00479
Pfam: Small Multidrug Resistance protein
InterPro:
Multidrug resistance protein, SMR family in PDB entry 6wk5, assembly 1, front view.
Multidrug resistance protein, SMR family in PDB entry 6wk5, assembly 1, side view.
Multidrug resistance protein, SMR family in PDB entry 6wk5, assembly 1, top view.
Molecule details ›

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L10 monobody
Chains: C, D
Length: 91 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
L10 monobody in PDB entry 6wk5, assembly 1, front view.
L10 monobody in PDB entry 6wk5, assembly 1, side view.
L10 monobody in PDB entry 6wk5, assembly 1, top view.
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