› 7b6r

Electron Microscopy
5.8Å resolution

Drosophila melanogaster TRAPPIII partial complex: core plus C8 and C11 attached region

Released:
DOI: 10.2210/pdb7b6r/pdb
PDB entry 7b6r coloured by chain, front view.
PDB entry 7b6r coloured by chain, side view.
PDB entry 7b6r coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
Galindo A, Planelles-Herrero VJ, Degliesposti G, Munro S
OpenAccess logo EMBO J 40 e107608 (2021)
PMID: 34018214
Related structures: EMD-12056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-106775 (preferred)
Entry contents:
9 distinct polypeptide molecules
Macromolecules (9 distinct):
FI18195p1 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.41 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q9VW22 (Residues: 355-661; Coverage: 23%)
Gene names: CG8793, Dmel\CG8793, Dmel_CG8793, TRAPPC8, l(3)76BDm, l(3)76BDm-RA, l(3)L3809
Sequence domains: ER-Golgi trafficking TRAPP I complex 85 kDa subunit
Trafficking protein particle complex subunit 11 Chain: B
Molecule details ›
Chain: B
Length: 718 amino acids
Theoretical weight: 81.85 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q8IRE3 (Residues: 1-718; Coverage: 54%)
Gene names: CG17569, Dmel\CG17569, Dmel_CG17569, TRAPPC11, gry, gryz, l(3)63Bd
Sequence domains: Foie gras liver health family 1
Trafficking protein particle complex subunit Chains: C, I
GEO08327p1 Chain: D
Trafficking protein particle complex subunit Chain: E
Trafficking protein particle complex subunit Chain: F
Probable trafficking protein particle complex subunit 2 Chain: G
Trafficking protein particle complex subunit 5 Chain: H
Trafficking protein particle complex subunit 2-like protein Chain: J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.8Å
Relevant EMDB volumes: EMD-12056
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017

Quick links

Citations

4 review citations

Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond.
Borchers et al. (2021)
3 more

3 mentions without citation

Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
Galindo et al. (2021)
2 more