› 7dst

Electron Microscopy
3.1Å resolution

FMDV capsid in complex with M170 Nab

Released:
DOI: 10.2210/pdb7dst/pdb
PDB entry 7dst coloured by chain, front view.
PDB entry 7dst coloured by chain, side view.
PDB entry 7dst coloured by chain, top view.
Source organisms:
Primary publication:
Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies.
Dong H, Liu P, Bai M, Wang K, Feng R, Zhu D, Sun Y, Mu S, Li H, Harmsen M, Sun S, Wang X, Guo H
OpenAccess logo Protein Cell 13 446-453 (2022)
PMID: 33599962
Related structures: EMD-30845

Function and Biology Details

Reactions catalysed: 
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-207287 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
VP1 protein Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 22.85 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: F8UF79 (Residues: 1-208; Coverage: 98%)
Gene name: VP1
Sequence domains: Picornavirus coat protein
VP2 of O type FMDV capsid Chain: B
Molecule details ›
Chain: B
Length: 206 amino acids
Theoretical weight: 23.09 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: A0A1V1FWA8 (Residues: 299-504; Coverage: 9%)
Sequence domains: picornavirus capsid protein
VP3 of O type FMDV capsid Chain: C
Molecule details ›
Chain: C
Length: 219 amino acids
Theoretical weight: 23.75 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: G8JKC1 (Residues: 505-723; Coverage: 9%)
Sequence domains: picornavirus capsid protein
VP4 of O type FMDV capsid Chain: D
Molecule details ›
Chain: D
Length: 75 amino acids
Theoretical weight: 7.96 KDa
Source organism: Foot-and-mouth disease virus
UniProt:
  • Canonical: A0A0K0QSS3 (Residues: 212-286; Coverage: 3%)
Sequence domains: Viral protein VP4 subunit
M170 Nab Chain: E
Molecule details ›
Chain: E
Length: 121 amino acids
Theoretical weight: 12.94 KDa
Source organism: Lama glama
Expression system: Lama glama

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-30845
Expression system: Lama glama

Quick links

Citations

1 review citation

A review of foot-and-mouth disease in Ethiopia: epidemiological aspects, economic implications, and control strategies.
Zewdie et al. (2023)
14 other articles

1 mention without citation

Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility.
Harmsen et al. (2022)