7dst

Electron Microscopy
3.1Å resolution

FMDV capsid in complex with M170 Nab

Released:

Function and Biology Details

Reactions catalysed:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-207287 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
VP1 protein Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 22.85 KDa
Source organism: Foot-and-mouth disease virus
VP2 of O type FMDV capsid Chain: B
Molecule details ›
Chain: B
Length: 206 amino acids
Theoretical weight: 23.09 KDa
Source organism: Foot-and-mouth disease virus
VP3 of O type FMDV capsid Chain: C
VP4 of O type FMDV capsid Chain: D
M170 Nab Chain: E

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-30845
Expression system: Lama glama