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X-ray crystal structure of VapB12 antitoxin from mycobacterium tuberculosis in space group P41.

X-ray diffraction
1.63Å resolution
PDB entry 7e4j coloured by chain, front view.
PDB entry 7e4j coloured by chain, side view.
PDB entry 7e4j coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Putative antitoxin VapB12
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Multimeric state: homo dimer
Accessible surface area: 5673.66 Å2
Buried surface area: 3045.03 Å2
Dissociation area: 1,522.51 Å2
Dissociation energy (ΔGdiss): 22.67 kcal/mol
Dissociation entropy (TΔSdiss): 10.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161669
Assembly 2 (preferred)
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Assembly Name: Putative antitoxin VapB12
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Multimeric state: homo dimer
Accessible surface area: 5568.12 Å2
Buried surface area: 3109.42 Å2
Dissociation area: 1,509.28 Å2
Dissociation energy (ΔGdiss): 30.51 kcal/mol
Dissociation entropy (TΔSdiss): 10.05 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161669

Macromolecules

Putative antitoxin VapB12
Chains: A, B, C, D
Length: 44 amino acids
Theoretical weight: 4.94 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P9WJ53 (Residues: 1-44; Coverage: 59%)
Gene names: Rv1721c, vapB12
Pfam: Antitoxin FitA-like, ribbon-helix-helix
InterPro: Ribbon-helix-helix
Putative antitoxin VapB12 in PDB entry 7e4j, assembly 2, front view.
Putative antitoxin VapB12 in PDB entry 7e4j, assembly 2, side view.
Putative antitoxin VapB12 in PDB entry 7e4j, assembly 2, top view.
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