Structure analysis

Cryo-EM structure of human TMEM120A in the CoASH-free state

Electron Microscopy
4Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 36932.67 Å2
Buried surface area: 3125.73 Å2
Dissociation area: 1,562.86 Å2
Dissociation energy (ΔGdiss): 16.27 kcal/mol
Dissociation entropy (TΔSdiss): 14.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-189791

Macromolecules

Chains: A, B
Length: 375 amino acids
Theoretical weight: 44.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXJ8 (Residues: 2-343; Coverage: 100%)
Gene names: TACAN, TMEM120A, TMPIT
Pfam: TMPIT-like protein
InterPro: Ion channel TACAN/TMEM120B

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