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Cryo-EM structure of human TMEM120A in the CoASH-free state

Electron Microscopy
4Å resolution
PDB entry 7f3u coloured by chain, front view.
PDB entry 7f3u coloured by chain, side view.
PDB entry 7f3u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ion channel TACAN
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Multimeric state: homo dimer
Accessible surface area: 36932.67 Å2
Buried surface area: 3125.73 Å2
Dissociation area: 1,562.86 Å2
Dissociation energy (ΔGdiss): 16.27 kcal/mol
Dissociation entropy (TΔSdiss): 14.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-189791

Macromolecules

Ion channel TACAN
Chains: A, B
Length: 375 amino acids
Theoretical weight: 44.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXJ8 (Residues: 2-343; Coverage: 100%)
Gene names: TACAN, TMEM120A, TMPIT
Pfam: TMPIT-like protein
InterPro: Ion channel TACAN/TMEM120B
Ion channel TACAN in PDB entry 7f3u, assembly 1, front view.
Ion channel TACAN in PDB entry 7f3u, assembly 1, side view.
Ion channel TACAN in PDB entry 7f3u, assembly 1, top view.
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