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eIF2B-SFSV NSs-1-eIF2

Electron Microscopy
2.76Å resolution
PDB entry 7f66 coloured by chain, front view.
PDB entry 7f66 coloured by chain, side view.
PDB entry 7f66 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentadecamer (preferred)
Entry contents: 9 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 2B complex
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Multimeric state: hetero pentadecamer
Accessible surface area: 184160.98 Å2
Buried surface area: 43188.85 Å2
Dissociation area: 2,654.55 Å2
Dissociation energy (ΔGdiss): -9.76 kcal/mol
Dissociation entropy (TΔSdiss): 36.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138584

Macromolecules

Translation initiation factor eIF2B subunit alpha
Chains: A, B
Length: 307 amino acids
Theoretical weight: 33.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14232 (Residues: 1-305; Coverage: 100%)
Gene names: EIF2B1, EIF2BA
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit alpha in PDB entry 7f66, assembly 1, front view.
Translation initiation factor eIF2B subunit alpha in PDB entry 7f66, assembly 1, side view.
Translation initiation factor eIF2B subunit alpha in PDB entry 7f66, assembly 1, top view.
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Translation initiation factor eIF2B subunit beta
Chains: C, D
Length: 351 amino acids
Theoretical weight: 39.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49770 (Residues: 1-351; Coverage: 100%)
Gene names: EIF2B2, EIF2BB
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit beta in PDB entry 7f66, assembly 1, front view.
Translation initiation factor eIF2B subunit beta in PDB entry 7f66, assembly 1, side view.
Translation initiation factor eIF2B subunit beta in PDB entry 7f66, assembly 1, top view.
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Translation initiation factor eIF2B subunit gamma
Chains: E, F
Length: 452 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR50 (Residues: 1-452; Coverage: 100%)
Gene name: EIF2B3
Pfam: Nucleotidyl transferase
InterPro:
Translation initiation factor eIF2B subunit gamma in PDB entry 7f66, assembly 1, front view.
Translation initiation factor eIF2B subunit gamma in PDB entry 7f66, assembly 1, side view.
Translation initiation factor eIF2B subunit gamma in PDB entry 7f66, assembly 1, top view.
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Translation initiation factor eIF2B subunit delta
Chains: G, H
Length: 523 amino acids
Theoretical weight: 57.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UI10 (Residues: 1-523; Coverage: 100%)
Gene names: EIF2B4, EIF2BD
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit delta in PDB entry 7f66, assembly 1, front view.
Translation initiation factor eIF2B subunit delta in PDB entry 7f66, assembly 1, side view.
Translation initiation factor eIF2B subunit delta in PDB entry 7f66, assembly 1, top view.
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Translation initiation factor eIF2B subunit epsilon
Chains: I, J
Length: 721 amino acids
Theoretical weight: 80.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13144 (Residues: 1-721; Coverage: 100%)
Gene names: EIF2B5, EIF2BE
Pfam: eIF4-gamma/eIF5/eIF2-epsilon
InterPro:
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f66, assembly 1, front view.
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f66, assembly 1, side view.
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f66, assembly 1, top view.
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Non-structural protein NS-S
Chains: K, L
Length: 261 amino acids
Theoretical weight: 29.7 KDa
Source organism: sandfly fever Sicilian virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P12792 (Residues: 7-267; Coverage: 98%)
Gene name: NSS
Pfam: Rift valley fever virus non structural protein (NSs) like
InterPro:
Non-structural protein NS-S in PDB entry 7f66, assembly 1, front view.
Non-structural protein NS-S in PDB entry 7f66, assembly 1, side view.
Non-structural protein NS-S in PDB entry 7f66, assembly 1, top view.
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Eukaryotic translation initiation factor 2 subunit 1
Chain: N
Length: 315 amino acids
Theoretical weight: 36.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05198 (Residues: 1-315; Coverage: 100%)
Gene names: EIF2A, EIF2S1
Pfam:
InterPro:
Eukaryotic translation initiation factor 2 subunit 1 in PDB entry 7f66, assembly 1, front view.
Eukaryotic translation initiation factor 2 subunit 1 in PDB entry 7f66, assembly 1, side view.
Eukaryotic translation initiation factor 2 subunit 1 in PDB entry 7f66, assembly 1, top view.
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eIF2beta
Chain: O
Length: 14 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
eIF2beta in PDB entry 7f66, assembly 1, front view.
eIF2beta in PDB entry 7f66, assembly 1, side view.
eIF2beta in PDB entry 7f66, assembly 1, top view.
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Eukaryotic translation initiation factor 2 subunit 3
Chain: S
Length: 472 amino acids
Theoretical weight: 51.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P41091 (Residues: 1-472; Coverage: 100%)
Gene names: EIF2G, EIF2S3
Pfam:
InterPro:
Eukaryotic translation initiation factor 2 subunit 3 in PDB entry 7f66, assembly 1, front view.
Eukaryotic translation initiation factor 2 subunit 3 in PDB entry 7f66, assembly 1, side view.
Eukaryotic translation initiation factor 2 subunit 3 in PDB entry 7f66, assembly 1, top view.
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