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Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.

Bajic G, Harrison SC
ACS Infect Dis 7 1-5 (2021)
Related entries: 7kqh, 7kqi

Cited: 7 times
EuropePMC logo PMID: 33274930

Abstract

We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.

Articles - 7kqg mentioned but not cited (1)

  1. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. Bajic G, Harrison SC. ACS Infect Dis 7 1-5 (2021)


Articles citing this publication (6)

  1. A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants. Schmitz AJ, Turner JS, Liu Z, Zhou JQ, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Altomare CG, Alsoussi WB, Case JB, VanBlargan LA, Lei T, Thapa M, Amanat F, Jeevan T, Fabrizio T, O'Halloran JA, Shi PY, Presti RM, Webby RJ, Krammer F, Whelan SPJ, Bajic G, Diamond MS, Boon ACM, Ellebedy AH. Immunity 54 2159-2166.e6 (2021)
  2. Antigen spacing on protein nanoparticles influences antibody responses to vaccination. Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP. Cell Rep 42 113552 (2023)
  3. Infant Antibody Repertoires during the First Two Years of Influenza Vaccination. Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito GC, Georgiou G, Walter EB, Kelsoe G, Harrison SC, Moody MA, Bajic G, Lee J. mBio 13 e0254622 (2022)
  4. Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine. Dzimianski JV, Han J, Sautto GA, O'Rourke SM, Cruz JM, Pierce SR, Ecker JW, Carlock MA, Nagashima KA, Mousa JJ, Ross TM, Ward AB, DuBois RM. Commun Biol 6 454 (2023)
  5. A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses. Simmons HC, Watanabe A, Oguin Iii TH, Van Itallie ES, Wiehe KJ, Sempowski GD, Kuraoka M, Kelsoe G, McCarthy KR. PLoS Biol 21 e3002415 (2023)
  6. Characterizing the dynamics of BCR repertoire from repeated influenza vaccination. Mai G, Zhang C, Lan C, Zhang J, Wang Y, Tang K, Tang J, Zeng J, Chen Y, Cheng P, Liu S, Long H, Wen Q, Li A, Liu X, Zhang R, Xu S, Liu L, Niu Y, Yang L, Wang Y, Yin D, Sun C, Chen YQ, Shen W, Zhang Z, Du X. Emerg Microbes Infect 12 2245931 (2023)


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