› 7kuy

Electron Microscopy
3.6Å resolution

Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state

Released:
DOI: 10.2210/pdb7kuy/pdb
PDB entry 7kuy coloured by chain, front view.
PDB entry 7kuy coloured by chain, side view.
PDB entry 7kuy coloured by chain, top view.
Source organisms:
Primary publication:
Characterization of the subunit composition and structure of adult human glycine receptors
Yu H, Bai X-C, Wang W
Neuron 109 2707-2716 (2021)
Related structures: EMD-23041

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149957 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycine receptor subunit alpha-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 364 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23416 (Residues: 28-343, 409-452; Coverage: 85%)
Gene name: GLRA2
Sequence domains:
Glycine receptor subunit beta; Green fluorescent protein Chain: E
Molecule details ›
Chain: E
Length: 702 amino acids
Theoretical weight: 78.77 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P48167 (Residues: 25-355, 400-497; Coverage: 90%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, GLRB
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 9 x NAG
Ligand SY9 5 x SY9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-23041
Expression system: Homo sapiens

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