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Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state

Electron Microscopy
3.6Å resolution
PDB entry 7kuy coloured by chain, front view.
PDB entry 7kuy coloured by chain, side view.
PDB entry 7kuy coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycine receptor
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Multimeric state: hetero pentamer
Accessible surface area: 66449.07 Å2
Buried surface area: 28469.99 Å2
Dissociation area: 5,202.67 Å2
Dissociation energy (ΔGdiss): 60 kcal/mol
Dissociation entropy (TΔSdiss): 15.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149957

Macromolecules

Glycine receptor subunit alpha-2
Chains: A, B, C, D
Length: 364 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23416 (Residues: 28-343, 409-452; Coverage: 85%)
Gene name: GLRA2
Pfam:
InterPro:
Glycine receptor subunit alpha-2 in PDB entry 7kuy, assembly 1, front view.
Glycine receptor subunit alpha-2 in PDB entry 7kuy, assembly 1, side view.
Glycine receptor subunit alpha-2 in PDB entry 7kuy, assembly 1, top view.
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Glycine receptor subunit beta; Green fluorescent protein
Chain: E
Length: 702 amino acids
Theoretical weight: 78.77 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P48167 (Residues: 25-355, 400-497; Coverage: 90%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
    • nullnull
Gene names: GFP, GLRB
Pfam:
InterPro:
Glycine receptor subunit beta in PDB entry 7kuy, assembly 1, front view.
Glycine receptor subunit beta in PDB entry 7kuy, assembly 1, side view.
Glycine receptor subunit beta in PDB entry 7kuy, assembly 1, top view.
Molecule details ›

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