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Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state

Source organisms:
Biochemical function: extracellular ligand-gated monoatomic ion channel activity
Biological process: monoatomic ion transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02932
Domain description: Neurotransmitter-gated ion-channel transmembrane region
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
The deposited structure of PDB entry 7kuy contains 4 copies of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Glycine receptor subunit alpha-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 7kuy contains 1 copy of Pfam domain PF02932 (Neurotransmitter-gated ion-channel transmembrane region) in Glycine receptor subunit beta. Showing 1 copy in chain E.

PF02931
Domain description: Neurotransmitter-gated ion-channel ligand binding domain
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
The deposited structure of PDB entry 7kuy contains 4 copies of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Glycine receptor subunit alpha-2. Showing 1 copy in chain A.
The deposited structure of PDB entry 7kuy contains 1 copy of Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) in Glycine receptor subunit beta. Showing 1 copy in chain E.

PF01353
Domain description: Green fluorescent protein
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein
The deposited structure of PDB entry 7kuy contains 1 copy of Pfam domain PF01353 (Green fluorescent protein) in Glycine receptor subunit beta. Showing 1 copy in chain E (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR006201
Domain description: Neurotransmitter-gated ion-channel
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR006028
Domain description: Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Occurring in:
  1. Glycine receptor subunit alpha-2
IPR008127
Domain description: Glycine receptor alpha
Occurring in:
  1. Glycine receptor subunit alpha-2
IPR000786
Domain description: Green fluorescent protein, GFP
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein
IPR036734
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR006029
Domain description: Neurotransmitter-gated ion-channel transmembrane domain
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR036719
Domain description: Neurotransmitter-gated ion-channel transmembrane domain superfamily
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR038050
Domain description: Neuronal acetylcholine receptor
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR018000
Domain description: Neurotransmitter-gated ion-channel, conserved site
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR006202
Domain description: Neurotransmitter-gated ion-channel ligand-binding domain
Occurring in:
  1. Glycine receptor subunit alpha-2
  2. Glycine receptor subunit beta; Green fluorescent protein
IPR009017
Domain description: Green fluorescent protein
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein
IPR011584
Domain description: Green fluorescent protein-related
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein
IPR047029
Domain description: Glycine receptor subunit beta, transmembrane domain
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein
IPR047031
Domain description: Glycine receptor subunit beta, extracellular domain
Occurring in:
  1. Glycine receptor subunit beta; Green fluorescent protein

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