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Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex

Electron Microscopy
3.3Å resolution
PDB entry 7l7i coloured by chain, front view.
PDB entry 7l7i coloured by chain, side view.
PDB entry 7l7i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 75522.29 Å2
Buried surface area: 16330.39 Å2
Dissociation area: 1,379.97 Å2
Dissociation energy (ΔGdiss): -4.7 kcal/mol
Dissociation entropy (TΔSdiss): 12.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139825

Macromolecules

Peptidyl-prolyl cis-trans isomerase FKBP5
Chain: C
Length: 457 amino acids
Theoretical weight: 51.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13451 (Residues: 1-457; Coverage: 100%)
Gene names: AIG6, FKBP5, FKBP51
Pfam:
InterPro:
Peptidyl-prolyl cis-trans isomerase FKBP5 in PDB entry 7l7i, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase FKBP5 in PDB entry 7l7i, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase FKBP5 in PDB entry 7l7i, assembly 1, top view.
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Heat shock protein HSP 90-alpha
Chains: A, B
Length: 732 amino acids
Theoretical weight: 84.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 1-732; Coverage: 100%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam:
InterPro:
Heat shock protein HSP 90-alpha in PDB entry 7l7i, assembly 1, front view.
Heat shock protein HSP 90-alpha in PDB entry 7l7i, assembly 1, side view.
Heat shock protein HSP 90-alpha in PDB entry 7l7i, assembly 1, top view.
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Prostaglandin E synthase 3
Chain: E
Length: 160 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15185 (Residues: 1-160; Coverage: 100%)
Gene names: P23, PTGES3, TEBP
Pfam: CS domain
InterPro:
Prostaglandin E synthase 3 in PDB entry 7l7i, assembly 1, front view.
Prostaglandin E synthase 3 in PDB entry 7l7i, assembly 1, side view.
Prostaglandin E synthase 3 in PDB entry 7l7i, assembly 1, top view.
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