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Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody fragments

Electron Microscopy
2.7Å resolution
PDB entry 7mhy coloured by chain, front view.
PDB entry 7mhy coloured by chain, side view.
PDB entry 7mhy coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein-cysteine N-palmitoyltransferase HHAT and IG-heavy chain and IG-light kappa chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero pentamer
Accessible surface area: 42025.09 Å2
Buried surface area: 7389.8 Å2
Dissociation area: 1,461.65 Å2
Dissociation energy (ΔGdiss): -7.77 kcal/mol
Dissociation entropy (TΔSdiss): 26.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212325

Macromolecules

Protein-cysteine N-palmitoyltransferase HHAT
Chain: A
Length: 493 amino acids
Theoretical weight: 57.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5VTY9 (Residues: 1-493; Coverage: 100%)
Gene names: HHAT, MART2, SKI1
Pfam: MBOAT, membrane-bound O-acyltransferase family
InterPro: Membrane bound O-acyl transferase, MBOAT
Protein-cysteine N-palmitoyltransferase HHAT in PDB entry 7mhy, assembly 1, front view.
Protein-cysteine N-palmitoyltransferase HHAT in PDB entry 7mhy, assembly 1, side view.
Protein-cysteine N-palmitoyltransferase HHAT in PDB entry 7mhy, assembly 1, top view.
Molecule details ›

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1C06 Fab heavy chain
Chain: M
Length: 211 amino acids
Theoretical weight: 22.85 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
1C06 Fab heavy chain in PDB entry 7mhy, assembly 1, front view.
1C06 Fab heavy chain in PDB entry 7mhy, assembly 1, side view.
1C06 Fab heavy chain in PDB entry 7mhy, assembly 1, top view.
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1C06 Fab light chain
Chain: N
Length: 207 amino acids
Theoretical weight: 22.9 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
1C06 Fab light chain in PDB entry 7mhy, assembly 1, front view.
1C06 Fab light chain in PDB entry 7mhy, assembly 1, side view.
1C06 Fab light chain in PDB entry 7mhy, assembly 1, top view.
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3H02 Fab heavy chain
Chain: O
Length: 211 amino acids
Theoretical weight: 23.23 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
3H02 Fab heavy chain in PDB entry 7mhy, assembly 1, front view.
3H02 Fab heavy chain in PDB entry 7mhy, assembly 1, side view.
3H02 Fab heavy chain in PDB entry 7mhy, assembly 1, top view.
Molecule details ›

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3H02 Fab light chain
Chain: P
Length: 207 amino acids
Theoretical weight: 22.87 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
3H02 Fab light chain in PDB entry 7mhy, assembly 1, front view.
3H02 Fab light chain in PDB entry 7mhy, assembly 1, side view.
3H02 Fab light chain in PDB entry 7mhy, assembly 1, top view.
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