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Cryo-EM reveals partially and fully assembled native glycine receptors,homomeric tetramer

Electron Microscopy
4.1Å resolution
PDB entry 7mlv coloured by chain, front view.
PDB entry 7mlv coloured by chain, side view.
PDB entry 7mlv coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycine receptor alpha 1 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero dodecamer
Accessible surface area: 97746.69 Å2
Buried surface area: 25455.18 Å2
Dissociation area: 10,997.93 Å2
Dissociation energy (ΔGdiss): -8.6 kcal/mol
Dissociation entropy (TΔSdiss): 139.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207844

Macromolecules

3D1 Fab Light Chain
Chains: I, J, K, M
Length: 107 amino acids
Theoretical weight: 11.74 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
InterPro:
3D1 Fab Light Chain in PDB entry 7mlv, assembly 1, front view.
3D1 Fab Light Chain in PDB entry 7mlv, assembly 1, side view.
3D1 Fab Light Chain in PDB entry 7mlv, assembly 1, top view.
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3D1 Fab Heavy Chain
Chains: F, G, H, L
Length: 118 amino acids
Theoretical weight: 12.98 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
InterPro:
3D1 Fab Heavy Chain in PDB entry 7mlv, assembly 1, front view.
3D1 Fab Heavy Chain in PDB entry 7mlv, assembly 1, side view.
3D1 Fab Heavy Chain in PDB entry 7mlv, assembly 1, top view.
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Glycine receptor alpha 1
Chains: A, B, C, D
Length: 456 amino acids
Theoretical weight: 52.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TUM3 (Residues: 1-456; Coverage: 100%)
Gene name: GLRA1
Pfam:
InterPro:
Glycine receptor alpha 1 in PDB entry 7mlv, assembly 1, front view.
Glycine receptor alpha 1 in PDB entry 7mlv, assembly 1, side view.
Glycine receptor alpha 1 in PDB entry 7mlv, assembly 1, top view.
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