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Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (apo-inward-open conformation)

Electron Microscopy
4.2Å resolution
PDB entry 7niu coloured by chain, front view.
PDB entry 7niu coloured by chain, side view.
PDB entry 7niu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylcholine translocator ABCB4 and IG-light kappa chain and IG-heavy chain and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero pentamer
Accessible surface area: 88546.6 Å2
Buried surface area: 11536.74 Å2
Dissociation area: 1,561.79 Å2
Dissociation energy (ΔGdiss): -11.79 kcal/mol
Dissociation entropy (TΔSdiss): 29.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210798

Macromolecules

Phosphatidylcholine translocator ABCB4
Chain: A
Length: 1279 amino acids
Theoretical weight: 140.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21439 (Residues: 1-1286; Coverage: 100%)
  • Best match: P21439-2 (Residues: 1-1279)
Gene names: ABCB4, MDR3, PGY3
Pfam:
InterPro:
Phosphatidylcholine translocator ABCB4 in PDB entry 7niu, assembly 1, front view.
Phosphatidylcholine translocator ABCB4 in PDB entry 7niu, assembly 1, side view.
Phosphatidylcholine translocator ABCB4 in PDB entry 7niu, assembly 1, top view.
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QA2 Fab-fragment light chain
Chain: D
Length: 215 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
QA2 Fab-fragment light chain in PDB entry 7niu, assembly 1, front view.
QA2 Fab-fragment light chain in PDB entry 7niu, assembly 1, side view.
QA2 Fab-fragment light chain in PDB entry 7niu, assembly 1, top view.
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QA2 Fab-fragment heavy chain
Chain: E
Length: 234 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
QA2 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, front view.
QA2 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, side view.
QA2 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, top view.
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4B1 Fab-fragment light chain
Chain: B
Length: 215 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
4B1 Fab-fragment light chain in PDB entry 7niu, assembly 1, front view.
4B1 Fab-fragment light chain in PDB entry 7niu, assembly 1, side view.
4B1 Fab-fragment light chain in PDB entry 7niu, assembly 1, top view.
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4B1 Fab-fragment heavy chain
Chain: C
Length: 241 amino acids
Theoretical weight: 25.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
4B1 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, front view.
4B1 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, side view.
4B1 Fab-fragment heavy chain in PDB entry 7niu, assembly 1, top view.
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