Function and Biology

Ternary complex of 14-3-3 sigma, Estrogen Receptor alfa phosphopeptide, and WQ136

Source organism: Homo sapiens
Biochemical function: protein sequestering activity
Biological process: negative regulation of stem cell proliferation
Cellular component: extracellular exosome

Sequence families

Pfam Protein families (Pfam)
PF12743
Domain description: Oestrogen-type nuclear receptor final C-terminal
Occurring in:
  1. Estrogen receptor
The deposited structure of PDB entry 7opw contains 1 copy of Pfam domain PF12743 (Oestrogen-type nuclear receptor final C-terminal ) in Estrogen receptor. Showing 1 copy in chain B.

PF00244
Domain description: 14-3-3 protein
Occurring in:
  1. 14-3-3 protein sigma
The deposited structure of PDB entry 7opw contains 1 copy of Pfam domain PF00244 (14-3-3 protein) in 14-3-3 protein sigma. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000308
Domain description: 14-3-3 protein
Occurring in:
  1. 14-3-3 protein sigma
IPR023409
Domain description: 14-3-3 protein, conserved site
Occurring in:
  1. 14-3-3 protein sigma
IPR023410
Domain description: 14-3-3 domain
Occurring in:
  1. 14-3-3 protein sigma
IPR036815
Domain description: 14-3-3 domain superfamily
Occurring in:
  1. 14-3-3 protein sigma
IPR024736
Domain description: Oestrogen-type nuclear receptor final C-terminal domain
Occurring in:
  1. Estrogen receptor
IPR037435
Domain description: 14-3-3 protein sigma
Occurring in:
  1. 14-3-3 protein sigma