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Ternary complex of 14-3-3 sigma, Estrogen Receptor alfa phosphopeptide, and WQ136

X-ray diffraction
1.81Å resolution
PDB entry 7opw coloured by chain, front view.
PDB entry 7opw coloured by chain, side view.
PDB entry 7opw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 21731.17 Å2
Buried surface area: 4979.6 Å2
Dissociation area: 910.75 Å2
Dissociation energy (ΔGdiss): 14.58 kcal/mol
Dissociation entropy (TΔSdiss): 11.22 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136921

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 253 amino acids
Theoretical weight: 28.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31947 (Residues: 1-248; Coverage: 100%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
InterPro:
14-3-3 protein sigma in PDB entry 7opw, assembly 1, front view.
14-3-3 protein sigma in PDB entry 7opw, assembly 1, side view.
14-3-3 protein sigma in PDB entry 7opw, assembly 1, top view.
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Estrogen receptor
Chain: B
Length: 15 amino acids
Theoretical weight: 1.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P03372 (Residues: 581-595; Coverage: 3%)
Gene names: ESR, ESR1, NR3A1
Pfam: Oestrogen-type nuclear receptor final C-terminal
InterPro: Oestrogen-type nuclear receptor final C-terminal domain
Estrogen receptor in PDB entry 7opw, assembly 1, front view.
Estrogen receptor in PDB entry 7opw, assembly 1, side view.
Estrogen receptor in PDB entry 7opw, assembly 1, top view.
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