› › Structure analysis

human DEPTOR in a complex with mutant human mTORC1 A1459P

Electron Microscopy
4.7Å resolution
PDB entry 7owg coloured by chain, front view.
PDB entry 7owg coloured by chain, side view.
PDB entry 7owg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 4 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: mTORC1 complex and DEP domain-containing mTOR-interacting protein
hide full assembly name
Multimeric state: hetero octamer
Accessible surface area: 315972.51 Å2
Buried surface area: 16999.29 Å2
Dissociation area: 2,662.44 Å2
Dissociation energy (ΔGdiss): -10.8 kcal/mol
Dissociation entropy (TΔSdiss): 52.85 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154636

Macromolecules

Serine/threonine-protein kinase mTOR
Chain: B
Length: 2549 amino acids
Theoretical weight: 287.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42345 (Residues: 1-2549; Coverage: 100%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam:
InterPro:
Serine/threonine-protein kinase mTOR in PDB entry 7owg, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 7owg, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 7owg, assembly 1, top view.
Molecule details ›

Search similar proteins

Target of rapamycin complex subunit LST8
Chain: E
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-326; Coverage: 100%)
Gene names: GBL, LST8, MLST8
Pfam: WD domain, G-beta repeat
InterPro:
Target of rapamycin complex subunit LST8 in PDB entry 7owg, assembly 1, front view.
Target of rapamycin complex subunit LST8 in PDB entry 7owg, assembly 1, side view.
Target of rapamycin complex subunit LST8 in PDB entry 7owg, assembly 1, top view.
Molecule details ›

Search similar proteins

DEP domain-containing mTOR-interacting protein
Chain: O
Length: 409 amino acids
Theoretical weight: 46.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TB45 (Residues: 1-409; Coverage: 100%)
Gene names: DEPDC6, DEPTOR
Pfam: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
InterPro:
DEP domain-containing mTOR-interacting protein in PDB entry 7owg, assembly 1, front view.
DEP domain-containing mTOR-interacting protein in PDB entry 7owg, assembly 1, side view.
DEP domain-containing mTOR-interacting protein in PDB entry 7owg, assembly 1, top view.
Molecule details ›

Search similar proteins

Regulatory-associated protein of mTOR
Chain: Y
Length: 1335 amino acids
Theoretical weight: 149.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N122 (Residues: 1-1335; Coverage: 100%)
Gene names: KIAA1303, RAPTOR, RPTOR
Pfam:
InterPro:
Regulatory-associated protein of mTOR in PDB entry 7owg, assembly 1, front view.
Regulatory-associated protein of mTOR in PDB entry 7owg, assembly 1, side view.
Regulatory-associated protein of mTOR in PDB entry 7owg, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links