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Mitochondrial DNA dependent RNA polymerase homodimer.

Electron Microscopy
3.5Å resolution
PDB entry 7pzp coloured by chain, front view.
PDB entry 7pzp coloured by chain, side view.
PDB entry 7pzp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA-directed RNA polymerase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 84004.86 Å2
Buried surface area: 2199.62 Å2
Dissociation area: 1,099.81 Å2
Dissociation energy (ΔGdiss): 1.52 kcal/mol
Dissociation entropy (TΔSdiss): 16.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-126267

Macromolecules

DNA-directed RNA polymerase, mitochondrial
Chains: A, B
Length: 1211 amino acids
Theoretical weight: 137.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00411 (Residues: 41-1230; Coverage: 97%)
Gene name: POLRMT
Pfam:
InterPro:
DNA-directed RNA polymerase, mitochondrial in PDB entry 7pzp, assembly 1, front view.
DNA-directed RNA polymerase, mitochondrial in PDB entry 7pzp, assembly 1, side view.
DNA-directed RNA polymerase, mitochondrial in PDB entry 7pzp, assembly 1, top view.
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