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S. cerevisiae CMGE nucleating origin DNA melting

Source organism: Saccharomyces cerevisiae
Biochemical function: protein binding
Biological process: DNA replication
Cellular component: nucleus

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF17855
Domain description: MCM AAA-lid domain
Occurring in:
  1. DNA replication licensing factor MCM3
  2. DNA replication licensing factor MCM4
  3. DNA replication licensing factor MCM6
  4. DNA replication licensing factor MCM7
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain A [auth 2].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain B [auth 3].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain C [auth 4].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain D [auth 6].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain E [auth 7].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17855 (MCM AAA-lid domain) in DNA replication licensing factor MCM5. Showing 1 copy in chain O [auth 5].

PF00493
Domain description: MCM P-loop domain
Occurring in:
  1. DNA replication licensing factor MCM3
  2. DNA replication licensing factor MCM4
  3. DNA replication licensing factor MCM6
  4. DNA replication licensing factor MCM7
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain A [auth 2].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain B [auth 3].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain C [auth 4].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain D [auth 6].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain E [auth 7].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF00493 (MCM P-loop domain) in DNA replication licensing factor MCM5. Showing 1 copy in chain O [auth 5].

PF17207
Domain description: MCM OB domain
Occurring in:
  1. DNA replication licensing factor MCM3
  2. DNA replication licensing factor MCM4
  3. DNA replication licensing factor MCM6
  4. DNA replication licensing factor MCM7
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain A [auth 2].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain B [auth 3].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain C [auth 4].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain D [auth 6].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain E [auth 7].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF17207 (MCM OB domain) in DNA replication licensing factor MCM5. Showing 1 copy in chain O [auth 5].

PF14551
Domain description: MCM N-terminal domain
Occurring in:
  1. DNA replication licensing factor MCM3
  2. DNA replication licensing factor MCM4
  3. DNA replication licensing factor MCM6
  4. DNA replication licensing factor MCM7
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM2. Showing 1 copy in chain A [auth 2].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain B [auth 3].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain C [auth 4].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain D [auth 6].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM7. Showing 1 copy in chain E [auth 7].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF14551 (MCM N-terminal domain) in DNA replication licensing factor MCM5. Showing 1 copy in chain O [auth 5].

PF05916
Domain description: GINS complex protein helical bundle domain
Occurring in:
  1. DNA replication complex GINS protein PSF3
  2. DNA replication complex GINS protein SLD5
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF05916 (GINS complex protein helical bundle domain) in DNA replication complex GINS protein PSF1. Showing 1 copy in chain F [auth H].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF05916 (GINS complex protein helical bundle domain) in DNA replication complex GINS protein PSF2. Showing 1 copy in chain G [auth I].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF05916 (GINS complex protein helical bundle domain) in DNA replication complex GINS protein PSF3. Showing 1 copy in chain H [auth C].
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF05916 (GINS complex protein helical bundle domain) in DNA replication complex GINS protein SLD5. Showing 1 copy in chain I [auth D].

PF22912
Domain description: Zinc finger domain of DNA polymerase-epsilon
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF22912 (Zinc finger domain of DNA polymerase-epsilon) in DNA polymerase epsilon catalytic subunit A. Showing 1 copy in chain L [auth G].

PF08490
Domain description: Domain of unknown function (DUF1744)
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF08490 (Domain of unknown function (DUF1744)) in DNA polymerase epsilon catalytic subunit A. Showing 1 copy in chain L [auth G].

PF22634
Domain description: DNA polymerase epsilon catalytic subunit A, thumb domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF22634 (DNA polymerase epsilon catalytic subunit A, thumb domain) in DNA polymerase epsilon catalytic subunit A. Showing 1 copy in chain L [auth G] (this domain is out of the observed residue ranges!).

PF03104
Domain description: DNA polymerase family B, exonuclease domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF03104 (DNA polymerase family B, exonuclease domain) in DNA polymerase epsilon catalytic subunit A. Showing 1 copy in chain L [auth G] (this domain is out of the observed residue ranges!).

PF04042
Domain description: DNA polymerase alpha/epsilon subunit B
Occurring in:
  1. DNA polymerase epsilon subunit B
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF04042 (DNA polymerase alpha/epsilon subunit B) in DNA polymerase epsilon subunit B. Showing 1 copy in chain K [auth F].

PF02724
Domain description: CDC45-like protein
Occurring in:
  1. Cell division control protein 45
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF02724 (CDC45-like protein) in Cell division control protein 45. Showing 1 copy in chain J [auth E].

PF16922
Domain description: DNA replication complex GINS protein SLD5 C-terminus
Occurring in:
  1. DNA replication complex GINS protein SLD5
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF16922 (DNA replication complex GINS protein SLD5 C-terminus) in DNA replication complex GINS protein SLD5. Showing 1 copy in chain I [auth D].

PF22466
Domain description: GINS/PriA/YqbF domain
Occurring in:
  1. DNA replication complex GINS protein PSF3
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF22466 (GINS/PriA/YqbF domain) in DNA replication complex GINS protein PSF3. Showing 1 copy in chain H [auth C].

PF18263
Domain description: MCM6 C-terminal winged-helix domain
Occurring in:
  1. DNA replication licensing factor MCM6
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF18263 (MCM6 C-terminal winged-helix domain) in DNA replication licensing factor MCM6. Showing 1 copy in chain D [auth 6] (this domain is out of the observed residue ranges!).

PF21128
Domain description: MCM4, winged helix domain
Occurring in:
  1. DNA replication licensing factor MCM4
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF21128 (MCM4, winged helix domain) in DNA replication licensing factor MCM4. Showing 1 copy in chain C [auth 4] (this domain is out of the observed residue ranges!).

PF22207
Domain description: MCM3 winged helix domain
Occurring in:
  1. DNA replication licensing factor MCM3
The deposited structure of PDB entry 7qhs contains 1 copy of Pfam domain PF22207 (MCM3 winged helix domain) in DNA replication licensing factor MCM3. Showing 1 copy in chain B [auth 3] (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR001208
Domain description: MCM domain
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR031327
Domain description: Mini-chromosome maintenance protein
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR008050
Domain description: DNA replication licensing factor Mcm7
Occurring in:
  1. DNA replication licensing factor MCM7
IPR041562
Domain description: MCM, AAA-lid domain
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR018525
Domain description: Mini-chromosome maintenance, conserved site
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR033762
Domain description: MCM OB domain
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM3
  3. DNA replication licensing factor MCM4
  4. DNA replication licensing factor MCM5
  5. DNA replication licensing factor MCM6
  6. DNA replication licensing factor MCM7
IPR008045
Domain description: DNA replication licensing factor Mcm2
Occurring in:
  1. DNA replication licensing factor MCM2
IPR008049
Domain description: DNA replication licensing factor Mcm6
Occurring in:
  1. DNA replication licensing factor MCM6
IPR008048
Domain description: DNA replication licensing factor Mcm5
Occurring in:
  1. DNA replication licensing factor MCM5
IPR008047
Domain description: Mini-chromosome maintenance complex protein 4
Occurring in:
  1. DNA replication licensing factor MCM4
IPR008046
Domain description: DNA replication licensing factor Mcm3
Occurring in:
  1. DNA replication licensing factor MCM3
IPR027925
Domain description: MCM, N-terminal domain
Occurring in:
  1. DNA replication licensing factor MCM2
  2. DNA replication licensing factor MCM4
  3. DNA replication licensing factor MCM5
  4. DNA replication licensing factor MCM6
  5. DNA replication licensing factor MCM7
IPR036224
Domain description: GINS, helical bundle-like domain superfamily
Occurring in:
  1. DNA replication complex GINS protein PSF3
  2. DNA replication complex GINS protein SLD5
  3. DNA replication complex GINS protein PSF1
  4. DNA replication complex GINS protein PSF2
IPR021151
Domain description: GINS subunit, domain A
Occurring in:
  1. DNA replication complex GINS protein PSF3
  2. DNA replication complex GINS protein SLD5
  3. DNA replication complex GINS protein PSF1
  4. DNA replication complex GINS protein PSF2
IPR007257
Domain description: DNA replication complex GINS protein Psf2
Occurring in:
  1. DNA replication complex GINS protein PSF2
IPR005339
Domain description: GINS complex, subunit Psf1
Occurring in:
  1. DNA replication complex GINS protein PSF1
IPR013697
Domain description: DNA polymerase epsilon, catalytic subunit A, C-terminal
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR003874
Domain description: CDC45 family
Occurring in:
  1. Cell division control protein 45
IPR008591
Domain description: GINS complex subunit Sld5
Occurring in:
  1. DNA replication complex GINS protein SLD5
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. DNA replication licensing factor MCM3
  2. DNA replication licensing factor MCM7
IPR042087
Domain description: DNA polymerase family B, thumb domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006134
Domain description: DNA-directed DNA polymerase, family B, multifunctional domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR023211
Domain description: DNA polymerase, palm domain superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006172
Domain description: DNA-directed DNA polymerase, family B
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR006133
Domain description: DNA-directed DNA polymerase, family B, exonuclease domain
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR029703
Domain description: DNA polymerase epsilon catalytic subunit
Occurring in:
  1. DNA polymerase epsilon catalytic subunit A
IPR007185
Domain description: DNA polymerase alpha/delta/epsilon, subunit B
Occurring in:
  1. DNA polymerase epsilon subunit B
IPR016266
Domain description: DNA polymerase epsilon, subunit B
Occurring in:
  1. DNA polymerase epsilon subunit B
IPR031633
Domain description: DNA replication complex GINS protein SLD5, C-terminal
Occurring in:
  1. DNA replication complex GINS protein SLD5
IPR038749
Domain description: GINS complex protein Sld5, alpha-helical domain
Occurring in:
  1. DNA replication complex GINS protein SLD5
IPR038437
Domain description: GINS complex, subunit Psf3 superfamily
Occurring in:
  1. DNA replication complex GINS protein PSF3
IPR010492
Domain description: GINS complex, subunit Psf3
Occurring in:
  1. DNA replication complex GINS protein PSF3
IPR041024
Domain description: Mcm6, C-terminal winged-helix domain
Occurring in:
  1. DNA replication licensing factor MCM6
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. DNA replication licensing factor MCM4

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